Anisomycin
22862-76-6
95%
Yes
2026-11-17
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Anisomycin Cat No CEI-0555 Description An activator of p54 and MAP kinases. Synergistic with growth factors and phorbol esters to superinduce cFas and c-Jun, by acting as a potent signaling agonist. Induces apoptosis in the human monoblastoid cell line. Appearance White to off-white solid Product Overview A MAP kinase activator CAS No 22862-76-6 Molecular Weight 348.52 Purity >95% (¹H NMR) Storage -20 centigrade Targets MAPK Molecular Formula C₁₄H₁₉NO₄ Chemical Name (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin Solubility DMSO or EtOH Shipping Conditions Gel pack category Antibiotics(c1416) cas_num 22862-76-6 ECHEMI Editorial ReferenceAnisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
(-)-anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. It has a role as an antiparasitic agent, a DNA synthesis inhibitor, a protein synthesis inhibitor, an antineoplastic agent, an antimicrobial agent, a bacterial metabolite and an anticoronaviral agent. It is a monohydroxypyrrolidine and an organonitrogen heterocyclic antibiotic.|Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis.|An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.
Crystalline
Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.Basic Info-
Product Name:
ANISOMYCIN
Other Name:(2R,3S,4S)-2-(4-METHOXYBENZYL)-3,4-PYRROLIDINEDOIL-3-ACETATE;(2R,3S,4S)-2-[(4-METHOXYPHENYL)METHYL]-3,4-PYRROLIDINEDIOL 3-ACETATE;2-(P-METHOXYBENZYL)-3,4-PYRROLIDINEDIOL-3-ACETATE;2-P-METHOXYPHENYLMETHYL-3-ACETOXY-4-HYDROXYPYRROLIDINE;1,4,5-trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate;ANISOMYCIN FROM STREPTOMYCES GRISEOLUS;3,4-Pyrrolidinediol, 2-(4-methoxyphenyl)methyl-, 3-acetate, (2R,3S,4S)-;(2R,3S,4S)-2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate
CAS No.:22862-76-6
Molecular Formula:C14H19NO4
InChIKeys:YKJYKKNCCRKFSL-RDBSUJKOSA-N
Molecular Weight:265.3
Exact Mass:265.30
BRN:20705
EC Number:245-269-7
UNII:6C74YM2NGI
NSC Number:76712
DSSTox ID:DTXSID5040966
Color/Form:white
HScode:29419090
Categories:
Characteristics-
λmax:
283nm(EtOH)(lit.)
PSA:67.8
XLogP3:0.42
Appearance:white solid
Density:1.1356 (rough estimate)
Melting Point:140-141 C
Boiling Point:408.52°C (rough estimate)
Flash Point:87℃
Refractive Index:1.5230 (estimate)
Water Solubility:Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml
Storage Conditions:2-8°C
Toxicity:LD50 orl-rat: 72 mg/kg ANTCAO 5,490,55
Flammability characteristics:Flammable; burning produces toxic nitrogen oxide fumes
Specific rotation:D23 -30° (methanol)
PKA:7.9(at 25℃)
Critical Temperature & Pressure:Inert atmosphere,Store in freezer, under -20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
