Zebularine
3690-10-6
Yes
2026-11-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Zebularine Cat No CEI-0558 Description Zebularine is a potent inhibitor of cytidine deaminase and DNA methylation; inhibits DNA methylation by forming a covalent complex with DNA methyltransferases (DNMTs). Displays antitumor properties. Alias NSC 309132 Appearance Liquid Product Overview A DNA methylation inhibitor CAS No 3690-10-6 Molecular Weight 455.89 Purity Single spot by TLC Storage -20 centigrade Synonyms NSC 309132 Targets MMP Molecular Formula C9H12N2O5 Chemical Name 1H-β-D-ribofuranosyl-2-pyrimidinone Shipping Conditions Gel pack category Inhibitors(c1514) cas_num 3690-10-6 ECHEMI Editorial ReferenceZebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor; also an inhibitor of cytidine deaminase with a Ki of 0.95 μM.
Zebularine is a member of pyrimidine ribonucleosides.|A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.|Zebularine is a synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions.Basic Info-
Product Name:
Zebularine
Other Name:2(1H)-Pyrimidinone,1-β-D-ribofuranosyl-;1-β-D-Ribofuranosyl-2(1H)-pyrimidinone;4-Deoxyuridine;1-(β-D-Ribofuranosyl)-2-pyrimidone;Uridine,4-deoxy-;Pyrimidin-2-one β-D-ribofuranoside;1-β-D-Ribofuranosyl-2-pyrimidinone;Zebularine;NSC 309132;1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one;22756-84-9
CAS No.:3690-10-6
Molecular Formula:C9H12N2O5
InChIKeys:InChIKey=RPQZTTQVRYEKCR-WCTZXXKLSA-N
Molecular Weight:228.203
Exact Mass:228.20
EC Number:2017-001-1
UNII:7A9Y5SX0GY
NCI Thesaurus Code:C37455
Categories:
Characteristics-
PSA:
103
XLogP3:-1.5
Appearance:solid
Density:1.7±0.1 g/cm3
Melting Point:183 °C
Boiling Point:499.0±55.0 °C at 760 mmHg
Flash Point:255.6±31.5 °C
Refractive Index:1.697
Water Solubility:DMSO: 16 mg/mL, soluble
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
