gamma-Secretase Modulators
937812-80-1
0.98%
Yes
2026-11-23
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Description
ProductName gamma-Secretase Modulators Cat No CEI-1343 Product Overview Oxadiazine is a potent modulator of γ-secretase with Aβ 42 IC50 value of 11 nM and Aβ total/ Aβ 42 value of 1170.γ-Secretase is one of intramenbrane-cleaving aspartyl protease which cleaves many type-I membrane proteins and many of them have important biological functions. γ-secretase is responsible for the generation Aβ from the amyloid precusor protein. γ-Secretase has been considered as an important drug target for Alzheimers disease. γ-Secertase also is responsible for Notch processing which is related to cancer such as leukemia. Oxadiazine is one analogues of BMS-869780 which is anotherγ-secretase modulator. It showed a four folds separation between the IC 50 of Aβ 42 and Aβ 40 H4-APPsw cells which overexpress APP protein. It also increase Aβ 37 and Aβ 38 levels whereas decrease Aβ 42 and Aβ 40 level. It also has little effect on APP-CTFα and no effect on APP-CTFβ and notch processing. It can significantly decrease Aβ 42 and Aβ 40 level in rat brain and plasma. CAS No 937812-80-1 Molecular Weight 483.49 Purity 0.98 Storage Store at -20°C Synonyms Amyloid-β production inhibitor; γ-Secretase Modulators Targets Amyloid-β Molecular Formula C26H24F3N3O3 Chemical Name (4R,7E,9aS)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 937812-80-1 ECHEMI Editorial Referencegamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease.IC50 value:Target: γ-secretase modulatorResearch & Reference Notegamma-Secretase Modulators is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Authoritative sourcesDisclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
Basic Info-
Product Name:
(E)-(4R,9aS)-7-[3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one
Other Name:(E)-(4R,9aS)-7-[3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one;HYR-141;Otamixaban;SynonyMs: HYR-141;gaMMa-Secretase Modulators;AMyloid-β production inhibitor;γ-Secretase Modulators;Pyrido[2,1-c][1,4]oxazin-6(1H)-one, hexahydro-7-[[3-Methoxy-4-(4-Methyl-1H-iMidazol-1-yl)phenyl]Methylene]-4-(3,4,5-trifluorophenyl)-, (4R,7E,9aS)-
CAS No.:937812-80-1
Molecular Formula:C26H24F3N3O3
InChIKeys:VHNYOQKVZQVBLC-RTCGXNAVSA-N
Molecular Weight:483.4822696
Exact Mass:483.17700
DSSTox ID:DTXSID90647302
Categories:
Characteristics-
PSA:
56.6
XLogP3:4.69040
Density:1.37g/cm3
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
