Combretastatin A4
117048-59-6
99%
2026-07-01
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Combretastatin A4 Cat No CEI-0566 Description A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/β-catenikt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. Alias CRC 87-09, NSC 817373 Appearance Crystalline solid Product Overview A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. CAS No 117048-59-6 Molecular Weight 376.41 Purity >99% by HPLC Storage -20 centigrade Synonyms CRC 87-09, NSC 817373 Targets Microtubule Molecular Formula C 18 H 20 O 5 Chemical Name 2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol Solubility DMSO (38 mg/ml) Shipping Conditions RT category Antineoplastic Agents(c1417) cas_num 117048-59-6 Basic Info-
Product Name:
Combretastatin A4
Other Name:Phenol,2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-;Phenol,2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-,(Z)-;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;Combretastatin A4;NSC 817373;CRC 87-09;NSC 613729;Combretastatin 4;CA 4;2′-Deoxycombretastatin A1;2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;cis-Combretastatin A4;Cis-Combretastatin A4;C 7744;848866-48-8;1052086-67-5
CAS No.:117048-59-6
Molecular Formula:C18H20O5
InChIKeys:InChIKey=HVXBOLULGPECHP-WAYWQWQTSA-N
Molecular Weight:316.3484
Exact Mass:316.35
HScode:29095000
Categories:
Characteristics-
PSA:
57.2
XLogP3:3.7
Appearance:off-white
Density:1.184±0.06 g/cm3(Predicted)
Melting Point:116-117 °C @ Solvent: Ethyl acetate
Boiling Point:490.3±45.0 °C(Predicted)
Flash Point:250.3±28.7 °C
Refractive Index:1.607
Water Solubility:DMSO: >10mg/mL
Storage Conditions:Desiccate at -20°C
Vapor Pressure:3.09E-10mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Serious eye damage, Category 1
Acute toxicity - Category 3, Inhalation
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H311 Toxic in contact with skin
H318 Causes serious eye damage
H331 Toxic if inhaled
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product