HIV-1 integrase inhibitor 2
957890-42-5
0.98%
2026-07-09
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName HIV-1 integrase inhibitor 2 Cat No CEI-1362 Description HIV-1 integrase inhibitor 2 is an inhibitor of HIV-1 integrase used in the treatment of human immunodeficiency virus (HIV) infection Product Overview The human immunodeficiency virus (HIV) is the causative agent for the acquired immunodeficiency syndrome (AIDS), then HIV integrase is an attractive target for new anti-HIV drugs. HIV-1 integrase inhibitor is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. CAS No 957890-42-5 Molecular Weight 353.84 Purity 0.98 Storage Store at -20°C Targets HIV-1 Molecular Formula C21H20ClNO2 Chemical Name 2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro On the basis of the available information, the authors synthesized several close analogs and discovered three new compounds with increased activity in vitro and in cell culture, thereby achieving an approximately tenfold increase of activity in AlphaScreen (IC50 = 1.37 ±0.36 μM) and a nearly 20-fold increase in antiviral activity (EC50 = 2.35 ±0.28 μM) for the most active compound, HIV-1 integrase inhibitor 2. The inter¬ action of LEDGF/p75 with neither JPO2 nor PogZ (cellular binding partners of LEDGF/p7527-29) was inhibited, suggesting binding of the compound to integrase and not to LEDGF/p75.HIV-1 integrase inhibitor 2 did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase. These findings point to a different mechanism of action than that observed for the strand-transfer inhibitors raltegravir and elvitegravir. No inhibitory activity of HIV-1 integrase inhibitor 2 was detected against HIV-1 reverse transcriptase. category Specialty Chemicals(c26) cas_num 957890-42-5 Basic Info-
Product Name:
6-Chloro-2-methyl-4-phenyl-alpha-propyl-3-quinolineacetic acid
Other Name:6-Chloro-2-methyl-4-phenyl-alpha-propyl-3-quinolineacetic acid;HIV-1 integrase inhibitor 2;3-Quinolineacetic acid, 6-chloro-2-Methyl-4-phenyl-a-propyl-;2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid
CAS No.:957890-42-5
Molecular Formula:C21H20ClNO2
InChIKeys:XRPUJSGGRFQZPJ-UHFFFAOYSA-N
Molecular Weight:353.842
Exact Mass:353.11800
DSSTox ID:DTXSID50647348
Categories:
Characteristics-
PSA:
50.19000
XLogP3:5.83190
Density:1.228
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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