MK-2894
1006036-87-8
0.98%
2026-07-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName MK-2894 Cat No CEI-1426 Description MK-2894 is a highly potent and selective inhibitor of EP4 receptor with IC50 value of 2.5 nM. Product Overview MK-2894 is a highly potent and selective inhibitor of EP4 receptor with IC50 value of 2.5 nM. MK-2894 is a highly selective and potent second generation EP4 antagonist with a Ki of 0.56±0.1nM in the radio ligand binding assay using membranes prepared from human EP1-4 overexpressed HEK 293 cell lines. And the EP4 functional assay measures the inhibition of PGE2-induced cAMP accumulation with IC50 of 2.5±0.7nM. In the AIA model and GI tolerability model in male SD rats, MK-2894 shows a dose-dependent inhibition of pain response with ED50 of 0.36 mg/kg. It also has the potent activity in inhibiting chronic pawswelling with ED50 of 0.02 mg/kg/day. Overall, MK-2894 displays the desired potency, selectivity, pharmacokinetic, and GI tolerability profile for further development and represents a potential safer alternative for treating pain and inflammation than traditional NSAIDs and coxibs. CAS No 1006036-87-8 Molecular Weight 473.51 Purity 0.98 Storage Store at -20°C Synonyms MK 2894; MK2894 Targets EP4 receptor IC50 2.5 nM (Ki=0.56±0.1 nM）; Molecular Formula C25H22F3NO3S Chemical Name 4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoic acid Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 1006036-87-8 Basic Info-
Product Name:
4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoicacid
Other Name:4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid;MK-2894;4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid;MK 2894;MK2894;Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-
CAS No.:1006036-87-8
Molecular Formula:C25H22F3NO3S
InChIKeys:QJZQFVRFJCGDKF-UHFFFAOYSA-N
Molecular Weight:473.51
Exact Mass:473.12724922
DSSTox ID:DTXSID60648063
Categories:
Characteristics-
PSA:
94.64000
XLogP3:6.48270
Density:1.39±0.1 g/cm3
Melting Point:254-256℃
Boiling Point:569.4±50.0 °C(Predicted)
PKA:4.35±0.10
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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