PD153035 hydrochloride
153436-54-5
0.97%
2026-07-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PD153035 hydrochloride Cat No CEI-1462 Description PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM. Product Overview PD153035 (4-(3-Bromoanilino)-6,7-dimethoxyquinazoline) is an extremely potent epidermal growth factor receptor (EGFR) inhibitor that competitively binds at the ATP site with the half maximal inhibition concentration IC50 of 0.025 nM resulting in the inhibition of the tyrosine kinase activity of the EGFR. PD153035 has been found to inhibit EGF-dependent EGFR phosphorylation in a variety of human cancer cell lines over-expressing EGFRs, which include A431, Difi, DU145, MDA-MB-468, ME180 and C4i, with IC50 of 0.22 μM, 0.3 μM, 0.4 μM, 0.68 μM, 0.95 μM and 2.5 μM respectively leading to suppression of proliferation and clonogenicity in those cell lines. Besides exerting potent inhibition against EGFRs, PD153035 also inhibits the closely related HER2/neu receptor but to a lesser degree CAS No 153436-54-5 Molecular Weight 396.67 Purity 0.97 Storage Store at RT Synonyms ZM252868,PD153035 HCL Targets EGFR IC50 5.2 pM (Ki); 29 pM Molecular Formula C16H14BrN3O2.HCl Chemical Name N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine Solubility Limited solubility Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 153436-54-5 Basic Info-
Product Name:
4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline
Other Name:4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-;N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine;PD 153035;4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline;WHI-P 79;AG 1517;SU 5271;4-(3-Bromophenylamino)-6,7-bis(methoxy)quinazoline;NSC 669364;(3-Bromophenyl)(6,7-dimethoxyquinazolin-4-yl)amine;GI 230329A;430475-82-4;197252-54-3
CAS No.:153436-54-5
Molecular Formula:C16H14BrN3O2
InChIKeys:InChIKey=LSPANGZZENHZNJ-UHFFFAOYSA-N
Molecular Weight:360.20 g/mol
Exact Mass:360.21
UNII:TC62B68RSL
DSSTox ID:DTXSID80165328
Categories:
Characteristics-
PSA:
56.3 Ų
XLogP3:3.49 (LogP)
Melting Point:189-190 °C
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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