4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline
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4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline
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CAS No:
153436-54-5
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Formula:
C16H14BrN3O2
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Chemical Name:
4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline
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Synonyms:
4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-;N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine;PD 153035;4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline;WHI-P 79;AG 1517;SU 5271;4-(3-Bromophenylamino)-6,7-bis(methoxy)quinazoline;NSC 669364;(3-Bromophenyl)(6,7-dimethoxyquinazolin-4-yl)amine;GI 230329A;430475-82-4;197252-54-3
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CAS No:
Description
PD-153035 is a member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic amine, a secondary amino compound, a member of bromobenzenes and an aromatic ether. It is a conjugate base of a PD-153035(1+).
4-(3-Bromophenylamino)-6,7-dimethoxyquinazoline Basic Attributes
360.20 g/mol
360.21
TC62B68RSL
DTXSID80165328
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline
Computed Properties
Molecular Weight:360.20
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:359.02694
Monoisotopic Mass:359.02694
Topological Polar Surface Area:56.3
Heavy Atom Count:22
Complexity:360
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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