Resminostat hydrochloride
1187075-34-8
0.98%
2026-08-07
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Resminostat hydrochloride Cat No CEI-1500 Product Overview Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6.As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266.This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53.In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study. CAS No 1187075-34-8 Molecular Weight 385.87 Purity 0.98 Storage Store at -20°C Synonyms RAS2410 hydrochloride; 4SC-201 hydrochloride; RAS 2410 hydrochloride; RAS-2410 hydrochloride Targets HDAC Molecular Formula C16H20ClN3O4S Chemical Name (Z)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide hydrochloride Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 1187075-34-8 Basic Info-
Product Name:
RAS-2410 hydrochloride
Other Name:4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS2410 hydrochloride;RAS-2410 hydrochloride;ResMinostat (hydrochloride);(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1);Resminostat HCl;RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201
CAS No.:1187075-34-8
Molecular Formula:C16H20ClN3O4S
InChIKeys:BVXPKDRKHXARHY-HAAWTFQLSA-N
Molecular Weight:385.8657
Exact Mass:385.0863050
Color/Form:White to off-white
Categories:
Characteristics-
Critical Temperature & Pressure:
Store at -20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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