Rofecoxib
162011-90-7
0.98%
2026-07-10
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Rofecoxib Cat No CEI-1511 Product Overview Rofecoxib is a potent and orally active inhibitor of cyclooxygenase (COX)-2 with IC50 value of 0.34μM. Rofecoxib is an inhibitor of COX-2 and is developed as a new class of anti-inflammatory agents with improved gastrointestinal tolerability. It has been shown to be effective in the treatment of osteoarthritis. Rofecoxib potently inhibits COX-2 in cell-based assays with IC50 values ranging from 18nM to 46nM. In osteosarcoma cells, rofecoxib prevents the production of PGE2 with IC50 value of 26nM. Rofecoxib also shows effective inhibition of recombinant human COX-2 in stably transfected CHO cells with IC50 value of 18nM. Besides that, rofecoxib inhibits the activity of purified human COX-2 with IC50 value of 0.34μM in the in vitro assay with Genapol X-100.In the carrageenan-induced rat paw edema assay, administration of rofecoxib suppresses the edema response with ID50 value of 1.5mg/kg. And in rats with carrageenan-induced paw hyperalgesia, relieves the hyperalgesia with ID50 value of 1mg/kg. CAS No 162011-90-7 Molecular Weight 314.36 Purity 0.98 Storage Store at-20°C Targets COX-2 Molecular Formula C17H14O4S Chemical Name 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Antipyretic Analgesics(c1413) cas_num 162011-90-7 Basic Info-
Product Name:
Rofecoxib
Other Name:2(5H)-Furanone,4-[4-(methylsulfonyl)phenyl]-3-phenyl-;4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone;3-Phenyl-4-[4-(Methylsulfonyl)phenyl]-2(5H)-furanone;MK 0966;Rofecoxib;MK 966;Vioxx;3-(4-Methanesulfonylphenyl)-2-phenyl-2-buten-4-olide;4-[4-(Methanesulfonyl)phenyl]-3-phenyl-5H-furan-2-one;Rhuma-cure;Ceeoxx;Ceoxx;Romacox;186912-82-3;2484980-39-2
CAS No.:162011-90-7
Molecular Formula:C17H14O4S
InChIKeys:InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N
Molecular Weight:314.36
Exact Mass:314.36
EC Number:1806241-263-5
UNII:0QTW8Z7MCR
NSC Number:758705|720256
DSSTox ID:DTXSID2023567
NCI Thesaurus Code:C1832
Color/Form:White to off-white to light yellow powder
ATC Code:M - Musculo-skeletal system
HScode:2932209090
Categories:
Characteristics-
PSA:
68.8
XLogP3:2.3
Appearance:white to beige
Density:1.333±0.06 g/cm3(Predicted)
Melting Point:207°C
Boiling Point:577.6±50.0 °C(Predicted)
Flash Point:303.1±30.1 °C
Refractive Index:1.619
Water Solubility:H2O: Insoluble ;DMSO: soluble 5mg/mL, clear (warmed)
Storage Conditions:Refrigerator
Vapor Pressure:3.2X10-9 mm Hg at 25 deg C /Estimated/
Henrys Law Constant:Henry's Law constant = 2.6X10-12 atm-cu m/mole at 25 °C /Estimated/
Experimental Properties:Hydroxyl radical reaction rate constant = 1.3X10-10 cu cm/ molecule-sec at 25 °C /Estimated/
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product