 Home > Encyclopedia > Piperazine

Piperazine

Piperazine structure

CAS No:
110-85-0
Formula:
C4H10N2
Chemical Name:
Piperazine
Synonyms:
Piperazine;Antiren;1,4-Diazacyclohexane;Diethylenediamine;Dispermine;Hexahydropyrazine;Lumbrical;Piperazidine;Pyrazine,hexahydro-;Pyrazine hexahydride;Pipersol;1,4-Piperazine;Wurmirazin;Worm-A-Ton;Eraverm;Uvilon;Vermex;NSC 474;Tetrahydro-1,4-diazine;8017-90-1;8027-81-4;81546-15-8;854880-15-2;861800-35-3
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Request for Quotation

Buy Piperazine

Description

HYGROSCOPIC COLOURLESS CRYSTALS OR WHITE FLAKES WITH PUNGENT ODOUR.

Piperazine Basic Attributes

Molecular Weight：

86.14

Exact Mass：

86.14

BRN：

102555

EC Number：

203-808-3

HScode：

2933599090

Characteristics

PSA：

24.1

XLogP3：

-1.17

Appearance：

White to slightly yellow Crystalline Flakes

Density：

1.1 g/cm³

Melting Point：

106 °C

Boiling Point：

146 °C @ Press: 760 Torr

Flash Point：

65 °C

Refractive Index：

1.424

Water Solubility：

H2O: 150 g/L (20 ºC)

Storage Conditions：

Store in dark!

Vapor Pressure：

0.8 mm Hg ( 20 °C)

Vapor Density：

Relative vapour density (air = 1): 3

Toxicity：

Oral-rat LD50: 1900 mg/kg; Oral-Mouse LD50: 600 mg/kg

Flammability characteristics：

Combustible; decomposes toxic nitrogen oxide gas in case of heat

Explosive limit：

14%

Odor：

Typical amine odor

Taste：

Salty taste

PH：

pH = 10.8-11.8 (10% aqueous solution)

PKA：

9.73None

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 2579 8/PG 3

wgk germany：

hazard class code：

34-42/43-52/53-62-52-63

safety instructions：

22-26-36/37/39-45-61

RTECS Number：

TK7800000

Marks：

C,Xn

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from acid

Hazard note：

Harmful/Corrosive

Explosive characteristics：

Explosive when mixed with air

Stability/Shelf Life：

Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338-P310

Hazard Statements：

H314-H317-H334-H361fd

Toxicity

Toxicity class：

moderately toxic

Piperazine Use and Manufacturing

Methods of Manufacturing

The preparation method is based on chloroethanol as the raw material, and is obtained through amination and cyclization. The process is to heat chloroethanol and ammonium hydroxide in an autoclave to an ammonia pressure of 441 kPa, stir the reaction for 5 hours, and recover excess ammonium hydroxide at normal pressure to obtain an aminoethanol aqueous solution. Add quantitative hydrochloric acid and stir, concentrate under reduced pressure to a semi-paste-like ethanolamine hydrochloride concentrate, warm up to 150°C, add paraffin wax that has been melted in advance, continue to heat up to 260°C, and maintain (260±2)°C for 12h , Filtration and removal of paraffin wax to obtain piperazine hydrochloride. Piperazine hydrochloride, solid sodium hydroxide, and water were added to the reaction kettle, stirred for 1.5h, and the ammonia was discharged. Then, the temperature was raised to 130-140°C, the piperazine hexahydrate solution was distilled off, the residue was filtered off, and the piperazine hexahydrate solution was frozen to At 8 ℃, centrifugal spin filtration to obtain piperazine hexahydrate, piperazine hexahydrate dehydration to obtain the finished piperazine. The reaction equation is as follows: ClCH2CH2OH+NH4OH→NH2CH2CH2OH·HCl+H2O

Uses

keratolytic, antiseborheic

Computed Properties

Molecular Weight:86.14
XLogP3:-1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:86.084398327
Monoisotopic Mass:86.084398327
Topological Polar Surface Area:24.1
Heavy Atom Count:6
Complexity:26.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

1,2-Dichloroethane

Ethylene glycol

Diethanolamine

Ammonium hydroxide

Ethanolamine

Ethylene oxide

Hydrocarbon waxes

Recommended Suppliers of Piperazine

Amitychem Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of chemicals

piperazine

Unit Price: $0.1 /KG EXW

CAS No.: 110-85-0

Grade: Different Grade

Content: 99.9%

Inquiry
SHANDONG LOOK CHEMICAL CO.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate,Pigment & Dyestuff,Polymer,Flavour & Fragrance,Basic Organic Chemicals,Pharmaceutical

Anhydrous Piperazine (PIP)

CAS No.: 110-85-0

Inquiry
M A M M TRANDING ENTERPRISE Contact Supplier

ZA
6 YRS

Business licensed

Trader Supplier of chemical

Piperazine Anhydrous 99% Powder SAA09989865546 SAA

Unit Price: $3500-3800 /MT FOB

CAS No.: 110-85-0

Grade: Food Grade

Content: 99%

Inquiry
NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

PiperazineCAS NO.110-85-0

CAS No.: 110-85-0

Grade: Industrial Grade

Content: 99%

Inquiry
Shanghai Lonwin Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of CHEMICALS,REAGENTS

High quality Piperazine CAS NO.110-85-0

CAS No.: 110-85-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry