Roflumilast
5 Inquiries
162401-32-3
2026-07-23
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Roflumilast Cat No CEI-1512 Product Overview Roflumilast is an orally active, selective inhibitor of phophodiesterase-4 (PDE-4) with IC50 value of 0.11nM. Roflumilast is developed for the treatment of the inflammatory component of COPD since PDE-4 is found mainly in inflammatory cells. In vitro studies show that roflumilast inhibits the production of inflammatory mediators in a variety of human immune cells, suggesting a role for reducing COPD-related inflammation. Roflumilast has a rapid absorption with a bioavailability of ~ 80% and the half-life is approximately 17h after repeated dosing of 500 mcg OD. Pharmacokinetic studies show no significant interactions with the drugs used by COPD patients. Roflumilast is also found to decrease glucose levels in patients with newly diagnosed type-2 diabetes since diabetes is an important comorbidity associated with COPD. CAS No 162401-32-3 Molecular Weight 403.21 Storage Store at -20°C Targets PDE-4 Molecular Formula C17H14Cl2F2N2O3 Chemical Name 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Respiratory Drugs(c1411) cas_num 162401-32-3 Basic Info-
Product Name:
Roflumilast
Other Name:Benzamide,3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;Roflumilast;BYK 20869;BY 217;B 9302-107;Daxas;Daliresp;ARQ 151;Libertek
CAS No.:162401-32-3
Molecular Formula:C17H14Cl2F2N2O3
InChIKeys:InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N
Molecular Weight:403.21
Exact Mass:403.21
EC Number:223-583-8
UNII:0P6C6ZOP5U
DSSTox ID:DTXSID8044123
NCI Thesaurus Code:C76890
ATC Code:R03DX07|R03DX08|R - Respiratory system
Categories:
Characteristics-
PSA:
60.4
XLogP3:4.6
Appearance:white to beige
Density:1.471±0.06 g/cm3(Predicted)
Melting Point:157-157.5 °C
Boiling Point:430.6±45.0 °C(Predicted)
Flash Point:214.2±28.7 °C
Refractive Index:1.604
Water Solubility:H2O: 0.52-0.56 mg/L at 22°C);DMSO: soluble 20mg/mL, clear
Storage Conditions:Refrigerator
Vapor Pressure:1.28E-07mmHg at 25°C
PKA:8.74None
Dissociation Constants:8.74
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted 
India
Roflumilast
1 G Jul 29, 2025 
United States
Roflumilast
10 G Jun 5, 2026
United States
Roflumilast
10 G May 9, 2026 
United Kingdom
Roflumilast
10 G Jul 29, 2025
India
Roflumilast
6 Jan 29, 2024 Post an enquiry for this product