China Largest factory Manufacturer Supply High Quality Roflumilast CAS 162401-32-3
GMP HALAL KOSHER ISO FDA TDS 6 Inquiries
162401-32-3
Pharmaceutical Grade
99.9%
China Port
Leader
25KG/Bag
Yes
2023-12-27
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceCrystallin SolidChEBI: A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary diseaseRoflumilast is a selective, orally active PDE4 inhibitor thatwas approvedin Germany in July 2010 as an add-on to bronchodilator treatment formaintenance therapy of severe chronic obstructive pulmonary disorder(COPD
Roflumilast is a benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease. It has a role as a phosphodiesterase IV inhibitor and an anti-asthmatic drug. It is a member of benzamides, a chloropyridine, an aromatic ether, an organofluorine compound and a member of cyclopropanes.|Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.|Roflumilast is a Phosphodiesterase 4 Inhibitor. The mechanism of action of roflumilast is as a Phosphodiesterase 4 Inhibitor.|Roflumilast is a selective inhibitor of phosphodiesterase-4 (PDE-4) that has unique antiinflammatory activity and is used to treat and prevent exacerbations of chronic obstructive pulmonary disease (COPD). Roflumilast has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.|Roflumilast is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3',5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling. cAMP prevents phosphorylation of spleen tyrosine kinase (SYK) and abrogates activation of the PI3K/AKT/mTOR signaling pathway, which may result in the induction of apoptosis. PDE4, a member of the PDE superfamily that hydrolyses cAMP and 3',5'-cyclic guanosine monophosphate (cGMP) to their inactive 5' monophosphates, is upregulated in a variety of cancers and may contribute to chemoresistance; it also plays a key role in inflammation, especially in inflammatory airway diseases.Certificates-
TDS
Basic Info-
Product Name:
Roflumilast
Other Name:Benzamide,3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;Roflumilast;BYK 20869;BY 217;B 9302-107;Daxas;Daliresp;ARQ 151;Libertek
CAS No.:162401-32-3
Molecular Formula:C17H14Cl2F2N2O3
InChIKeys:InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N
Molecular Weight:403.21
Exact Mass:403.21
EC Number:223-583-8
UNII:0P6C6ZOP5U
DSSTox ID:DTXSID8044123
NCI Thesaurus Code:C76890
ATC Code:R03DX07|R03DX08|R - Respiratory system
Categories:
Characteristics-
PSA:
60.4
XLogP3:4.6
Appearance:white to beige
Density:1.471±0.06 g/cm3(Predicted)
Melting Point:157-157.5 °C
Boiling Point:430.6±45.0 °C(Predicted)
Flash Point:214.2±28.7 °C
Refractive Index:1.604
Water Solubility:H2O: 0.52-0.56 mg/L at 22°C);DMSO: soluble 20mg/mL, clear
Storage Conditions:Refrigerator
Vapor Pressure:1.28E-07mmHg at 25°C
PKA:8.74None
Dissociation Constants:8.74
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
5 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
Above 1000
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Year of Establishment:
2014
Company Certificates-
Level A of Tax Credit Registration Assessment by Government
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Good Product Quality Management Certificate of Shanxi Province,China
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Company Trade Union Qualification Certificate
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Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
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AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
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FDA
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Inquiry History6 Inquiries
Country Product Purchase Quantity Date Posted
India
Roflumilast
1 G Jul 29, 2025
Australia
Roflumilast
1 G Sep 17, 2026
United States
Roflumilast
10 G Jun 5, 2026
United States
Roflumilast
10 G May 9, 2026
United Kingdom
Roflumilast
10 G Jul 29, 2025
India
Roflumilast
6 Jan 29, 2024 Post an enquiry for this product
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