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Home > Inorganic Chemistry > Inorganic Salts > Roflumilast for Sale > China Largest factory Manufacturer Supply High Quality Roflumilast CAS 162401-32-3
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China Largest factory Manufacturer Supply High Quality Roflumilast CAS 162401-32-3

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Unit Price: Get Latest Price
CAS No.:

162401-32-3

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

China Port

Brand:

Leader

Packaging:

25KG/Bag

Price valid (until):

2023-12-27

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      About Product Technical Details  


    Product Name: Roflumilast
    Synonyms: ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
    CAS: 162401-32-3
    MF: C17H14Cl2F2N2O3
    MW: 403.21
    EINECS: 685-382-2
    Product Categories: Roflumilast;Daxas;Inhibitors;Intermediates & Fine Chemicals;APIs;API;All Inhibitors;Pharmaceuticals;162401-32-3
    Mol File: 162401-32-3.mol
    Shop China Largest factory Manufacturer Supply High Quality Roflumilast CAS 162401-32-3-Detailed Image 1

    Roflumilast Chemical Properties
    Melting point  158°C
    Boiling point  430.6±45.0 °C(Predicted)
    density  1.471±0.06 g/cm3(Predicted)
    storage temp.  -20°C
    solubility  DMSO: soluble20mg/mL, clear
    pka 9.89±0.70(Predicted)
    form  powder
    color  white to beige
    Merck  14,8249
    Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
    InChIKey MNDBXUUTURYVHR-UHFFFAOYSA-N
    SMILES C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
    CAS DataBase Reference 162401-32-3(CAS DataBase Reference)


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      About Our Group


            Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture high quality raw materials and refined ingredients which is widely used at different industries areas like Pharm & chemicals industry, functional active ingredients industry, nutritional Ingredients industry, health care products industry, cosmetics industry,  pharmaceutical and refined food, feed, oil industry, natural plant ingredients industries, agriculture industry etcs to provide top quality of GMP standards products.

            All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, agriculture raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China.

            Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates.

           With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people.

           We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  

           We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.



      Our Factories Production Lines  



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      Our Factories R&D ability  



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      Our Factories warehouse 52000㎡


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      Sales Team  


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    Certificates
    • China Largest factory Manufacturer Supply High Quality Roflumilast CAS 162401-32-3 Certificates 7

    Basic Info
    Product Name:

    Roflumilast

    Other Name:

    Benzamide,3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;Roflumilast;BYK 20869;BY 217;B 9302-107;Daxas;Daliresp;ARQ 151;Libertek

    CAS No.:

    162401-32-3

    Molecular Formula:

    C17H14Cl2F2N2O3

    InChIKeys:

    InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N

    Molecular Weight:

    403.21

    Exact Mass:

    403.21

    EC Number:

    223-583-8

    UNII:

    0P6C6ZOP5U

    DSSTox ID:

    DTXSID8044123

    NCI Thesaurus Code:

    C76890

    ATC Code:

    R03DX07|R03DX08|R - Respiratory system

    Categories:

    Inorganic Salts

    Characteristics
    PSA:

    60.4

    XLogP3:

    4.6

    Appearance:

    white to beige

    Density:

    1.471±0.06 g/cm3(Predicted)

    Melting Point:

    157-157.5 °C

    Boiling Point:

    430.6±45.0 °C(Predicted)

    Flash Point:

    214.2±28.7 °C

    Refractive Index:

    1.604

    Water Solubility:

    H2O: 0.52-0.56 mg/L at 22°C);DMSO: soluble 20mg/mL, clear

    Storage Conditions:

    Refrigerator

    Vapor Pressure:

    1.28E-07mmHg at 25°C

    PKA:

    8.74None

    Dissociation Constants:

    8.74

    Hazard Identification

    Classification of the substance or mixture

    Skin irritation, Category 2

    Eye irritation, Category 2

    Specific target organ toxicity – single exposure, Category 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P319 Get medical help if you feel unwell.

    Storage

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

    Location:

    National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    5

    Total Annual Revenue:

    $10 million-$25 million

    Total Employees:

    Above 1000

    Year of Establishment:

    2014

    Certifications:

    Level A of Tax Credit Registration Assessment by Government,Good Product Quality Management Certificate of Shanxi Province,China,Company Trade Union Qualification Certificate,Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina,AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China,FDA


    24 Hours Team Service

    Email

    info@leader-biogroup.com   

    Hot Line

    +86-029-68895030  

    +86-029-68569961  

    +86-029-68569962  

    Fax

    +86-029-68895030


    Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories Base with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world.

    • Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.

      Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.

      Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.

      We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

    • Process Capability :   It has more than 100 sets of multi-functional reaction reactors, such as 100l~6300l enamel, stainless steel, Hastelloy, etc. It can realize Grignard, coupling, bromination, Wittig reaction and other conventional reactions. There are microchannel reactor workshops, which can realize continuous production, energy conservation and emission reduction. It can realize high pressure, high vacuum rectification, ultra-low temperature (-80 ℃ ~-100 ℃), ultra-high temperature (300 ℃ ~400 ℃) and other special reactions. It can realize the customization and processing of customers' products.

                                      

        Factory Overview

                                                                                 Factory Production Lines

    Our Professional Lab

                               Factory Warehouse 

    Factory Logistics Departments

    GROUP HONOR

    Honor Name: Level A of Tax Credit Registration Assessment   
    Issued By:National Administration of Taxation & Shaanxi Tax Bureau   
    Authorised Date:2018-09-16  
    Description: National Administration of Taxation & Shaanxi Tax Bureau




    Honor Name: AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China  
    Issued By:China Association of Shaanxi product Quality management Center   
    Authorised Date:2018-12-31  
    Description:AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China



    Honor Name:Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina

    Issued By: China Association of Shaanxi product Quality management Center

    Authorised Date:2018-12-31

    Description: Excellent Group Enterprise of Quality and Integrity in Shaanxi Province,China



    Honor Name: Products Patent Certificates


  • Inquiry History
    5 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Roflumilast

    1 G Jul 29, 2025
    United States

    Roflumilast

    10 G Jun 5, 2026
    United States

    Roflumilast

    10 G May 9, 2026
    United Kingdom

    Roflumilast

    10 G Jul 29, 2025
    India

    Roflumilast

    Jan 29, 2024
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