ST 2825
894787-30-5
0.98%
2026-07-26
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName ST 2825 Cat No CEI-1535 Description ST 2825 is an inhibitor of MyD88 pharmacologic Product Overview ST 2825 is a specific inhibitor of MyD88 dimerization. ST 2825 is a synthetic compound which mimics the structure of the heptapeptide in the BB-loop of the MyD88-TIR domain and interferes the homodimerization of MyD88. ST 2825 was proved to specifically inhibit the homodimerization of MyD88 TIR domains without affecting the homodimerization of death domains. In HEK293T cells transfected with Flag-MyD88 and Myc-MyD88, ST 2825 inhibited the interaction of the two MyD88 by 80% at the concentration of 10 μM. This inhibition resulted in the subsequent interference of the IRAK1 and IRAK4 recruitment. Besides that, administration of ST 2825 significantly inhibited the IL-6 production stimulated by IL-1β at doses of 100 and 200 mg/kg in mice. Furthermore, 8 μM ST 2825 completely blocked the TLR9-induced B cell proliferation. ST2825 also suppressed the generation of plasma cells induced by CpG dose-dependently. CAS No 894787-30-5 Molecular Weight 591.51 Purity 0.98 Storage Store at -20°C Synonyms ST2825; ST-2825 Targets MyD88 Molecular Formula C27H28Cl2N4O5S Chemical Name (4R,7R,8aR)-1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]-6-oxospiro[3,4,8,8a-tetrahydro-2H-pyrrolo[2,1-b][1,3]thiazine-7,2-pyrrolidine]-4-carboxamide Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 894787-30-5 Basic Info-
Product Name:
(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
Other Name:894787-30-5;ST 2825;ST2825;ST-2825;(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;CHEMBL408178;SCHEMBL14265201;DTXSID30647407;s8466;ZINC29134880
CAS No.:894787-30-5
Molecular Formula:C27H28Cl2N4O5S
InChIKeys:HBLHLJXFIPCEMW-ZJSFPPFMSA-N
Molecular Weight:591.5
Exact Mass:590.1157466
DSSTox ID:DTXSID30647407
Categories:
Characteristics -
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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