Tolcapone
2 Inquiries
134308-13-7
0.98%
2026-09-19
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Tolcapone Cat No CEI-1558 Product Overview Tolcapone is a novel, reversible and orally-bioavailable small-molecule catechol-O-methyltransferase (COMT) inhibitor used for as an adjunct to levodopa therapy for the treatment of Parkinson's disease (PD). The chemical structure of tolcapone contains a catechol structure with two electron withdrawing substituents of a tendency to easily deliver a proton resulting in an anion that is highly affinitive for COMT (the value of 50% inhibition concentration IC50 of 36 nM in rat liver) and displaces other catechols (such as catecholamines and levodopa) from the COMT catalytic center to prevent methylation. Study results have that the use of tolcapone reduces the dosage but enhances the therapeutic effects of levodopa to control PD symptoms. ReferenceTruong DD. Tolcapone: review of its pharmacology and use as adjunctive therapy in patients with Parkinsons disease. CAS No 134308-13-7 Molecular Weight 273.24 Purity 0.98 Storage Store at -20°C Synonyms Ro 40-7592, Ro-40-7592 Targets COMT Molecular Formula C14H11NO5 Chemical Name (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Inhibitors(c1514) cas_num 134308-13-7 ECHEMI Editorial ReferenceYellow SolidTolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pKa＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney.Basic Info-
Product Name:
Tolcapone
Other Name:Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-;(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone;Ro 40-7592;Tolcapone;3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone;Tasmar
CAS No.:134308-13-7
Molecular Formula:C14H11NO5
InChIKeys:InChIKey=MIQPIUSUKVNLNT-UHFFFAOYSA-N
Molecular Weight:273.24
Exact Mass:273.24
UNII:CIF6334OLY
DSSTox ID:DTXSID3023685
NCI Thesaurus Code:C47762
ATC Code:N04BX01|N - Nervous system
HScode:2914710000
Categories:
Characteristics-
PSA:
103
XLogP3:3.3
Appearance:yellow
Density:1.419±0.06 g/cm3(Predicted)
Melting Point:141-143 °C
Boiling Point:485.6±45.0 °C(Predicted)
Flash Point:205.7±17.2 °C
Refractive Index:1.661
Water Solubility:DMSO: ≥15mg/mL
Storage Conditions:-20°C Freezer
Hazard IdentificationClassification of the substance or mixture
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H400 Very toxic to aquatic life
Precautionary statement(s) Prevention P273 Avoid release to the environment.
Response P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Tolcapone
10 G Oct 4, 2023 
Croatia
Tolcapone
50 KG Jan 31, 2024 Post an enquiry for this product