Zanamivir
139110-80-8
0.98%
2026-07-21
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Zanamivir Cat No CEI-1592 Product Overview Zanamivir is a selective inhibitor of influenza A and B virus neuraminidases with IC50 values of 0.64-7.9nM. Influenza A and B viruses are negative-strand RNA viruses. Neuraminidase is one of the two glycoproteins present on the surface of the virus. It is important to the pathogenicity and infectivity of the virus. The neuraminidases inhibitor, zanamivir, is a sialic acid analogue. It inhibits neuraminidases to cleave sialic acid on the surface of host cells and influenza viral envelope. In the in vitro assay, zanamivir suppresses the growth of influenza A and B viruses with IC50 values ranging from 5nM to 14nM for laboratory-passaged strains and from 20nM to 16μM for clinical isolates. In animal models infected with influenza A and B, treatment of zanamivir reduces the mortality and viral titres in lung homogenates and improves lung consolidation scores. CAS No 139110-80-8 Molecular Weight 332.31 Purity 0.98 Storage Store at-20°C Targets Neuraminidases Molecular Formula C12H20N4O7 Chemical Name (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid Solubility Limited solubility Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Antibiotics(c1416) cas_num 139110-80-8 Basic Info-
Product Name:
Zanamivir
Other Name:D-glycero-D-galacto-Non-2-enonic acid,5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-;5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid;4-Guanidino-Neu5Ac2en;GG 167;GR 121167X;Zanamivir;GANA;GANA (inhibitor);4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid;Relenza;Zanamir;5-Acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid;(2R,3R,4S)-4-Guanidino-3-(prop-1-en-2-ylamino)-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid;Zanamvir;Zanamiwei;Dectova;720666-86-4;851070-78-5;1537183-66-6;2305982-64-1
CAS No.:139110-80-8
Molecular Formula:C12H20N4O7
InChIKeys:InChIKey=ARAIBEBZBOPLMB-UFGQHTETSA-N
Molecular Weight:332.31
Exact Mass:332.31
EC Number:1592732-453-0
UNII:L6O3XI777I
DSSTox ID:DTXSID0023749
NCI Thesaurus Code:C47786
Color/Form:White to off-white powder
ATC Code:J05AH01|J - Antiinfectives for systemic use
HScode:2932999000
Categories:
Characteristics-
PSA:
201
XLogP3:-3.2
Appearance:white to beige
Density:1.75±0.1 g/cm3(Predicted)
Melting Point:253-255 °C
Refractive Index:1.679
Water Solubility:H2O: soluble10mg/mL, clear
Storage Conditions:-20°C Freezer
Vapor Pressure:4.4X10-18 mm Hg at 25 deg C (est)
Specific rotation:D20 +40.9° (c = 0.9 in water)
Henrys Law Constant:Henry's Law constant = 4.6X10-30 atm-cu m/mol at 25 °C (est)
Experimental Properties:Colorless crystals /Sesquihydrate/|Hydroxyl radical reaction rate constant = 2.1X10-10 cu cm/molec-sec at 25 °C (est)|Zwitterionic at physiological pH.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product