Thiamine pyrophosphate

The active coenzyme form of vitamin B1 which functions in aldehyde transfer reactions.
Thiamine(1+) diphosphate chloride is an organic chloride salt of thiamine(1+) diphosphate. It is an organic chloride salt and a vitamin B1. It contains a thiamine(1+) diphosphate.|The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
Best known as the anti-beriberi factor and called at first simply vitamin B by McCollum, thiamine was shown to be involved in the decarboxylation of pyruvate to acetaldehyde in alcohol fermentation and was named ‘cocarboxylase’ in 1932. Confirmation of its structure as TPP came 5 years later. Its name is meant to signify a vitamin containing sulfur (thios in Greek).
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine pyrophosphate is a coenzyme of transketolase that catalyzes the cleavage of ribulose-5-phosphate; thereby forming D-glyceraldehyde-3-phosphate. This reaction requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde.