high quality Pergolide Mesylate 99% transparent liquid KANBEI
HALAL ISO
66104-23-2
Industrial Grade
99%
QINGDAO
KANBEI
25kg drum
2023-10-08
PVC resin,pvc paste resin,melamine
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferencePergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.Target: Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabe
Pergolide mesylate is a methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. It has a role as an antiparkinson drug, a dopamine agonist and a geroprotector. It contains a pergolide(1+).|Pergolide is an oral dopamine receptor agonist used predominantly in the therapy of Parkinson disease. Pergolide therapy is associated with low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury.|Pergolide Mesylate is a semi-synthetic ergot derivative and a dopamine agonist with antiparkinson property. Pergolide mesylate binds to and activates dopamine receptor subtypes D1 and D2, resulting in prolactin secretion inhibition, transient increase in serum concentration of growth hormone, and decrease in serum concentration of luteinizing hormone. Direct stimulation of postsynaptic dopamine receptors in the nigrostriatal system, may account for this agent's antiparkinson activity.|A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.CertificatesBasic Info-
Product Name:
Pergolide mesylate
Other Name:Ergoline,8-[(methylthio)methyl]-6-propyl-,(8β)-,monomethanesulfonate;Indolo[4,3-fg]quinoline,ergoline deriv.;Pergolide mesylate;LY 127809;Pergolide methanesulfonate;Permax;Celance;NSC 319773;138932-34-0
CAS No.:66104-23-2
Molecular Formula:C19H26N2S.CH4O3S
InChIKeys:InChIKey=UWCVGPLTGZWHGS-ZORIOUSZSA-N
Molecular Weight:410.59
Exact Mass:410.169769
UNII:55B9HQY616
NSC Number:758442|319773
DSSTox ID:DTXSID6040583
NCI Thesaurus Code:C47665
HScode:2939690000
Categories:
Characteristics-
PSA:
107
XLogP3:4.79380
Appearance:white
Melting Point:225 °C
Boiling Point:491.3ºC at 760 mmHg
Flash Point:250.9ºC
Water Solubility:ethanol: soluble 2mg/mL
Storage Conditions:−20°C
Specific rotation:aD20 between -18.0° and -23.0° (c = 10 mg/ml in DMF)
Collision Cross Section:177.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
PVC resin,pvc paste resin,melamine
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Location:
Room 405, Unit 2, Building 1, Taiji Mansion, No. 38, Nanyang Road, Jinshui District, Zhengzhou City, Henan Province
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
90 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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