Biperiden
514-65-8
Mumbai Port
Drum
2023-06-01
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Product Description
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DescriptionECHEMI Editorial ReferenceBiperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.Target: M1 receptorsBiperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on
Solid
Biperiden is a member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease. It has a role as a muscarinic antagonist, a parasympatholytic, an antiparkinson drug, an antidyskinesia agent and an antidote to sarin poisoning. It is a member of piperidines, a tertiary amino compound and a tertiary alcohol.|A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.|Biperiden is an Anticholinergic. The mechanism of action of biperiden is as a Cholinergic Antagonist.|Biperiden is an oral anticholinergic agent used predominantly in the symptomatic therapy of Parkinson disease and movement disorders. Biperiden has not been associated with serum enzyme elevations during treatment and must be a very rare cause of clinically apparent acute liver injury, if it occurs at all.Basic Info-
Product Name:
Biperiden
Other Name:1-Piperidinepropanol,α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-;1-Piperidinepropanol,α-5-norbornen-2-yl-α-phenyl-;α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol;α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinopropanol;Biperiden;α-5-Norbornen-2-yl-α-phenyl-1-piperidinepropanol;KL 373;Akineton;1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;107629-33-4
CAS No.:514-65-8
Molecular Formula:C21H29NO
InChIKeys:InChIKey=YSXKPIUOCJLQIE-UHFFFAOYSA-N
Molecular Weight:311.46106
Exact Mass:311.46
EC Number:208-184-6
UNII:0FRP6G56LD
NSC Number:759145
DSSTox ID:DTXSID6022680
Color/Form:Crystals
ATC Code:N04AA02|N - Nervous system
HScode:2933399090
Categories:
Characteristics-
PSA:
23.5
XLogP3:4.1
Appearance:Solid
Density:1.1±0.1 g/cm3
Melting Point:114 °C
Boiling Point:462.1±40.0 °C at 760 mmHg
Flash Point:224.5±26.0 °C
Refractive Index:1.583
Water Solubility:H2O: 25.1 mg/L
Storage Conditions:Biperiden hydrochloride tablets should be stored in tight, light-resistant containers at 15-30 deg C.
Vapor Pressure:5.42 mm Hg at 25 deg C (est)
Toxicity:Oral-rat LD50: 750 mg/kg; Oral-Mouse LD50: 530 mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxide fumes
Henrys Law Constant:Henry's Law constant = 2.44X10-10 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 9.74 (amine) (est)
Collision Cross Section:175.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Hydroxyl radical reaction rate constant = 1.79X10-10 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Biperiden hydrochloride tablets should be stored in tight, light-resistant containers at 15-30 deg C.
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