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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > PVM/MA for Sale > PVM/MA, Vorasidenib 99% white powder 1644545-52-7 Senwayer
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PVM/MA, Vorasidenib 99% white powder 1644545-52-7 Senwayer

4 Inquiries

Unit Price: Get Latest Price
CAS No.:

1644545-52-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Senwayer

Packaging:

500g/ bag 25kg/ drum

Sample Available:

Yes

Price valid (until):

2023-03-16

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,L/C
Average Lead Time:
10 days
Qualification:
Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

  • Product Details

  • Seller Information

  • Inquiry History

  • Description


      Product Information  


    Vorasidenib was well tolerated and showed preliminary antitumor activity in patients with recurrent or progressive nonenhancing mIDH LGG.

    Product name PVM/MA
    CAS No. 1644545-52-7
    MF C14H13ClF6N6
    MW 414.74
    Boiling point 467.5±55.0 °C(Predicted)
    Density 1.491±0.06 g/cm3(Predicted)
    Storage N/A


      About us  


    Wuhan senwayer century chemical Co.,Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
    We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
    Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
    We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
    With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
    If you are interested, pls contact me freely!

    ECHEMI Editorial Reference
    Vorasidenib is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. Upon administration, vorasidenib specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations. In addition, vorasidenib is able to penetrate the blood-brain barrier (BBB). IDH1 and 2, metabolic enzymes that catalyze the conversion of isocitrate into a-KG, play key roles in energy production and are mutated in a variety of cancer cell types. In addition, mutant forms of IDH1 and 2 catalyze the formation of 2HG and drive cancer growth by blocking cellular differentiation and inducing cellular proliferation.

    Basic Info
    Product Name:

    PVM/MA

    Other Name:

    PF06291874;E-7386;FM381 FM-381;6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine;PVM/MA;S-N-NITROSO-2-METHYLPIPERIDINE;PCB138/160;FLEABUSTERSRXPOWDER

    CAS No.:

    1644545-52-7

    Molecular Formula:

    C14H13ClF6N6

    InChIKeys:

    QCZAWDGAVJMPTA-RNFRBKRXSA-N

    Molecular Weight:

    414.74

    Exact Mass:

    414.0794411

    UNII:

    789Q85GA8P

    NCI Thesaurus Code:

    C152914

    Color/Form:

    Light yellow to light brown

    Characteristics
    Density:

    1.491±0.06 g/cm3(Predicted)

    Boiling Point:

    467.5±55.0 °C(Predicted)

    PKA:

    1.49±0.41(Predicted)

    Critical Temperature & Pressure:

    Store at -20°C

  • Seller Information
    Business Type:

    Trader

    Main Products:

    API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

    Location:

    Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

    Payment Terms:

    TT against copy of documents,L/C

    Average lead Time:

    10 days

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    51-100

    Year of Establishment:

    2020

    Company Certificates
    • Dingwang Technology (Wuhan) Co., Ltd.Verified supplier certificate Verified supplier certificate
    • Dingwang Technology (Wuhan) Co., Ltd.SGS SGS
      Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
          We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.

    Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
           We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
         With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
  • Inquiry History
    4 Inquiries
    Country Product Purchase Quantity Date Posted
    Pakistan

    Vorasidenib

    1 G May 17, 2026
    Pakistan

    Vorasidenib

    100 MG May 19, 2026
    Pakistan

    Vorasidenib

    100 G May 18, 2026
    Pakistan

    Vorasidenib

    1 KG May 27, 2025
    Post an enquiry for this product
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