PVM/MA, Vorasidenib 99% white powder 1644545-52-7 Senwayer
4 Inquiries
1644545-52-7
Pharmaceutical Grade
99%
shanghai
Senwayer
500g/ bag 25kg/ drum
Yes
2023-03-16
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceVorasidenib is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. Upon administration, vorasidenib specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations. In addition, vorasidenib is able to penetrate the blood-brain barrier (BBB). IDH1 and 2, metabolic enzymes that catalyze the conversion of isocitrate into a-KG, play key roles in energy production and are mutated in a variety of cancer cell types. In addition, mutant forms of IDH1 and 2 catalyze the formation of 2HG and drive cancer growth by blocking cellular differentiation and inducing cellular proliferation.Basic Info
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Product Name:
PVM/MA
Other Name:PF06291874;E-7386;FM381 FM-381;6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine;PVM/MA;S-N-NITROSO-2-METHYLPIPERIDINE;PCB138/160;FLEABUSTERSRXPOWDER
CAS No.:1644545-52-7
Molecular Formula:C14H13ClF6N6
InChIKeys:QCZAWDGAVJMPTA-RNFRBKRXSA-N
Molecular Weight:414.74
Exact Mass:414.0794411
UNII:789Q85GA8P
NCI Thesaurus Code:C152914
Color/Form:Light yellow to light brown
Categories:
Characteristics-
Density:
1.491±0.06 g/cm3(Predicted)
Boiling Point:467.5±55.0 °C(Predicted)
PKA:1.49±0.41(Predicted)
Critical Temperature & Pressure:Store at -20°C
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Seller Information
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Business Type:
Trader
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Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid
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Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
10 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
51-100
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Year of Establishment:
2020
Company Certificates-
Verified supplier certificate
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SGS
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Inquiry History4 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
Vorasidenib
1 G May 17, 2026
Pakistan
Vorasidenib
100 MG May 19, 2026
Pakistan
Vorasidenib
100 G May 18, 2026
Pakistan
Vorasidenib
1 KG May 27, 2025 Post an enquiry for this product
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