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XAZB Supply Hirudin 98% CAS: 113274-56-9

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CAS No.:

113274-56-9

Grade:

Pharmaceutical Grade

Content:

98%

Packaging:

1kg;25kgs

Price valid (until):

2023-05-31

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Xian ZB Biotech Co.,Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

8 days

Qualification:

Main Products:

Herb Extracts,Cosmetic raw materails,API

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Product Description
Seller Information

Description

Product Detail

INTRODUCTION

Recombinant Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech. Hirudin acts directly on thrombin rather than through other clotting factors. The mechanism of Hirudin-thrombin appears to be unique. The conversion of fibrinogen into fibrin by the serine protease enzyme thrombin is a major event in the final stages of blood coagulation. In the final stages of coagulation prothrombinase converts prothrombin into thrombin. Fibrin is subsequently cross linked by factor XIII to form a blood clot. The primary inhibitor of thrombin in normal blood circulation is antithrombin III. The anticoagulatant activity of hirudin is derived from its ability to inhibit the pro-coagulant activity of thrombin (similar to antithrombin III activity). Hirudin is the strongest natural inhibitor of thrombin. Hirudin binds to and inhibits only the activity of thrombin forms with a specific activity on fibrinogen contrasting to antithrombin III activity. Therefore, hirudin has a thrombolytic activity since it prevents or dissolves the formation of clots and thrombi. Hirudin also has therapeutic significance in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins. Hirudin does not hinder with the biological activity of other serum proteins and can also act on complexed thrombin, thus having an advantage over more common anticoagulants and thrombolytics. It is complicated to extract large quantities of hirudin from natural sources; therefore a method for producing and purifying hirudin using recombinant biotechnology has been developed.

DESCRIPTION

Recombinant Hirudin is derived from yeast and the polypeptide chain contains 65 amino acids and its Mw is 6979.5 Dalton which is identical to natural Hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.
The Recombinant Hirudin is purified by proprietary chromatographic techniques.

SOURCE

Pichia Pastoris.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

Each mg of protein was lyophilized from a sterile solution containing 20mM PBS pH-7 and 2% mannitol.

SOLUBILITY

It is recommended to reconstitute the lyophilized Hirudin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

STABILITY

Lyophilized Hirudin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Hirudin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

PURITY

Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

BIOLOGICAL ACTIVITY

The specific activity was found to be >14,000ATU/mg.

SAFETY DATA SHEET

SDS

USAGE

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Basic Info

Product Name:

HIRUDIN (54-65) (DESULFATED)

Other Name:

HIRUDIN (54-65) (DESULFATED);HIRUDIN FRAGMENT 54-65 NON-SULFATED;H-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH;GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN;Hirudin

CAS No.:

113274-56-9

Molecular Formula:

C66H93N13O25

InChIKeys:

ZNEKMMIWGPUTGR-SQJOKQRMSA-N

Molecular Weight:

1468.52

Exact Mass:

1467.640503

DSSTox ID:

DTXSID60583167

Categories:

Blood System Drugs

Characteristics

PSA:

624.45000

XLogP3:

-0.19

Density:

1.384±0.06 g/cm3(Predicted)

Boiling Point:

1913.6±65.0 °C(Predicted)

Flash Point:

1111.1±34.3 °C

Refractive Index:

1.587

Storage Conditions:

−20°C

See More HIRUDIN (54-65) (DESULFATED) Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More HIRUDIN (54-65) (DESULFATED) Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Herb Extracts,Cosmetic raw materails,API

Location:
1403,Jinye B Block

Payment Terms:
TT against copy of documents

Average lead Time:
8 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2015

Xian ZB Biotech Co.,Ltd is a leading Manufactory supplier of Arbutin, Nicotinamide, Flucytosine based in Xi'an, Shaanxi, China. With a commitment to quality and customer satisfaction, Xian ZB Biotech Co.,Ltd has become a trusted name in the industry. Our product line includes a range of high-quality Arbutin, Nicotinamide, Flucytosine, which are available at competitive prices. Xian ZB Biotech Co.,Ltd has established itself as a reliable supplier of chemical products on the echemi.com.
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