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Betadex Sulfobutyl Ether Sodium(SBE-β-CD) Injection grade EP/USP

Name: Betadex Sulfobutyl Ether Sodium(SBE-β-CD) Injection grade EP/USP
Brand: HANDOM CHEM
SKU: pr2305121311
Price: 120 USD
Availability: InStock

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CAS No.:

182410-00-0

Grade:

Pharmaceutical Grade

Content:

95%

Port:

Dalian

Brand:

HANDOM CHEM

Packaging:

10kg/drum or 20kg/drum

Price valid (until):

2023-07-31

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DALIAN HANDOM CHEMICALS CO.,LTD.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Product Name: Betadex Sulfobutyl Ether Sodium

Alias: Sulfobutyl Ether-β-cyclodextrin; Sulfobutyl ether-beta-cyclodextrin sodium salt
Abbreviation: SBECD; SBE-β-CD
CAS No.: 182410-00-0
Molecular Formula: C42H70-nO35 (C4H8O3S Na)n
Appearance: white powder, non-toxic, odorless, slightly sweet
Product Specification: Injection grade
Quality Standard: USP/EP

Test Items		Specifications
Appearance		White to off-white amorphous powder
Solubility		Very soluble in water, sparingly soluble in Methanol, practically insoluble in Ethanol, N-Hexane, 1-Butanol, Acetonitrile, 2-Propanol and Ethyl Acetate.
Identification	IR	Same absorption bands as USP betadex sulfobutyl ether sodium RS.
	HPLC	The retention time of the major peak of Sample solution corresponds to that of the Standard solution.
	Average degree of substitution	Conforms
	Sodium	Identify tests are positive for Sodium
Assay(On Dried Basis)		95.0% ~ 105.0%
Betadex		Not more than 0.1%
1,4-Butane Sultone		Not more than 0.5ppm
Sodium Chloride		Not more than 0.2%
4-Hydroxybutane-1-Sulfonic Acid		Not more than 0.09%
Bis(4-Sulfobutyl) Ether Disodium		Not more than 0.05%
Bacterial Endotoxins		Not more than 0.02EU/mg
The Total Aerobic Microbial Counts		Not more than 100CFU/g
The Total Combined Moulds and Yeasts Counts		Not more than 50CFU/g
Escherichia coli		Negative
Clarity of Solution		30%(w/v) solution is clear and essentially free from particles of foreign matters.
Average Degree of Substitution		6.2 ~ 6.9
Peaks Ⅰ-Ⅹ(% peak area)	Ⅰ	0.0 ~ 0.3
	Ⅱ	0.0 ~ 0.9
	Ⅲ	0.5 ~ 5.0
	Ⅳ	2.0 ~ 10.0
	Ⅴ	10.0 ~ 20.0
	Ⅵ	15.0 ~ 25.0
	Ⅶ	20.0 ~ 30.0
	Ⅷ	10.0 ~ 25.0
	Ⅸ	2.0 ~ 12.0
	Ⅹ	0.0 ~ 4.0
pH Value		4.0 ~ 6.8
Water Determination		Not more than 10.0%

Description:

The betadex sulfobutyl ether sodium produced by HDC CHEM is the product of substitution reaction between β-cyclodextrin and 1,4-butane sultone. The glucose unit of beta cyclodextrin is formed by linking 7 pyranose through a-1, 4 glycosidic bonds. The substitution reaction occurs at the 2, 3, and 6 carbon hydroxyl positions of the β-CD glucose unit, and the obtained product is a substitution SBECD with a degree of 6.2-6.9, the structure diagram is as follows:

[Product Features]

It can be used as solubilizer, wetting agent, chelating agent (complexing agent), multivalent masking agent. Sodium sulfobutylbeta cyclodextrin is a new type of anionic highly water-soluble cyclodextrin derivative, which can be well included with drug molecules to form non-covalent complexes, thereby improving the stability, water solubility and safety of drugs. It can reduce nephrotoxicity, alleviate drug hemolysis, control drug release rate, mask bad smell, etc. It has good solubilization, convenient drug administration, safety and stability.Compared with beta-cyclodextrin (β-CD), Betadex sulfobutyl ether sodium has better water solubility, less hemolysis, and lower nephrotoxicity. It is a new type of medicinal drug with very broad application prospects Accessories.

[Product Performance]

1. Solubilization:Neutral, positive and negative drug substances can be effectively combined with Sulfobutyl Ether-β-cyclodextrin, so that compounds with different solubility in the drug substance can be increased by 10 to 25000 times.

2. Convenient Drug Administration:

Sulfobutyl Ether-β-cyclodextrin has good biocompatibility and can be administered by injection, oral, ophthalmic, nasal, topical and inhalation.

3. Good Security:

It is generally rapidly and completely eliminated from the kidneys after administration. In vitro experiments and in vivo acute, subacute and chronic toxicity studies provide safety data and are approved for human pharmaceutical formulations.

4. Good Stability:

The interaction with sulfobutylbeta cyclodextrin can provide a beneficial protective environment for the drug substance in its lipophilic cavity, while the hydrophilic surface provides excellent water solubility to provide solubility and stability.

[Application Cases]

Betadex sulfobutyl ether sodium is often used in insoluble compounds, such as Voriconazole, Carfilzomib, Ziprasidone, Aripiprazole, Maropitant (Animal Medicine), Posaconazole, Carbamazepine, Melphalan, Delafloxacin, Mebendazole, Topiramate, Omeprazole, Clopidogrel, Docetaxel, Sofosbuvir, Ziprasidone Mesylate, Meloxicam, Tetrahydroprogesterone, and several other nitrogenous API bases are in various clinical stages.

[Specific Applications In The Products]

1. Application in Injection(1) Function: Solubilizer, stabilizer, improve the solubility and stability of insoluble drugs, and make insoluble drugs developed into injections.

(2) Example: Use betadex sulfobutyl ether sodium to improve the solubility of Voriconazole, Posaconazole, Delafloxacin, Docetaxel, Ibuprofen and Indomethacin; Using betadex sulfobutyl ether sodium to improve the stability of Carmustine.

2. Application in Oral Preparations(1) Function: Solubilizer, stabilizer, improve the bioavailability of insoluble drugs.

(2) Example: Improve the bioavailability of Flunarizine, Danazol, Prednisolone and Prasugrel with Sulfobutyl Ether-β-cyclodextrin.

3. Application in Ophthalmic Preparations(1) Function: Solubilizer, stabilizer, reduce drug irritation.

(2) Example: Use Sulfobutyl Ether-β-cyclodextrin to improve the irritation and stability of Pilocarpine, Dipivefrin, Balofloxacin and Ganciclovir.

4. Application in Nasal Preparations(1) Function: Increase the permeability of the nasal mucosa, improve the solubility and stability of the drug, and improve the metabolic rate of the target drug.

(2) Example: Using Sulfobutyl Ether-β-cyclodextrin to improve the solubility and stability of Midazolam.

5. Ointment(1) Function: Improve the solubility and stability of drugs.

(2) Example: Using betadex sulfobutyl ether sodium to improve the solubility and stability of Nimesulide.

Packaging:
1) Inner Packing: Sterile PE Bag + Aluminum Foil Bag;
2) Outer Packing: Cardboard Drum(Fibre Drum) or Carton.
3) Packing Specification(Injection Grade): 10kg/drum or 20kg/drum.

Storage Conditions:
Preserved in unopened original containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.

Shelf Life:
24 months if stored under above mentioned conditions.

Basic Info

Product Name:

β-Cyclodextrin, sulfobutyl ethers, sodium salts

Other Name:

β-Cyclodextrin,sulfobutyl ethers,sodium salts

CAS No.:

182410-00-0

Molecular Weight:

1134.9842

EC Number:

1308068-626-2

Categories:

Chiral Chemicals

Characteristics

See More β-Cyclodextrin, sulfobutyl ethers, sodium salts Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More β-Cyclodextrin, sulfobutyl ethers, sodium salts Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2020

Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Cyprus	Betadex Sulfobutyl Ether Sodium(SBE-β-CD) Injection grade EP/USP	1 KG	Oct 15, 2024

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