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Semaglutide 99% (recombinant)

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CAS No.:

910463-68-2

Grade:

Pharmacy Grade(for injection or for tablet)

Content:

99%

Port:

Any port in China

Packaging:

Double layer polyethylene bag , single-layer aluminum-plastic film bag

Price valid (until):

2023-05-31

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First Rays Co.,Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Functional Food Ingredients (Chondroitin sulfate),3,5-di-tert-butylsalicylic acid,TBPB,Cosmetic Ingredients(PDRN&PN, EGT,HA, Ectoine),API & Intermediates(Semaglutide&related products),Agrochemicals

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Product Description
Seller Information
Inquiry History

Description

Purity：>99% (for injection), >98% (for tablets)

Indications:

1. An adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus .

2. To reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease

3. May help adults and children aged 12 years and older with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to help them lose weight and keep the weight off.

Mechanism of Action:

Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1. Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor, the target for native GLP-1.

GLP-1 is a physiological hormone that has multiple actions on glucose, mediated by the GLP-1 receptors.

( *Still in patent, so only for R&D use )

Items	Specifications	Test Result
Appearance	White or almost white powder	White powder
Chromatographic Identification	The retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the Assay	Meet requirement
Peptide Mapping	The chromatographic profile of the sample solution corresponds to that of the standard solution	Meet requirement
pH	6.0~9.0	6.8
Specific optical rotation	-6°~ -16°	Meet requirement
Assay	It contains 0.76 mg to 1.00 mg of semaglutide(C187H291N45O59) per mg	It contains 0.94 mg of semaglutide per mg
Related Substance	Total impurities NMT 5.5%	Total impurities NMT1%, individual impurity is superior to RLD
High Molecular Weight Protein	NMT 0.3%	Meet requirement
Water Content	NMT 10.0%	5.5%
Bacterial Endotoxins Tests	NMT 10 IU/mg	Meet requirement
Microbial Enumeration Tests	The total aerobic count does not exceed 100CFU/g	Meet requirement
Host Cell Protein	NMT 100 ppm	Meet requirement
Host Cell DNA	NMT 10 ng/mg	Meet requirement
Bioassay	0.7~1.3 unit/mg	0.8 unit/mg
Residual Solvents (TBD)	USP <467>	Meet USP <467> requirement

ECHEMI Editorial Reference

Semaglutide (CAS: 910463‑68‑2) is a synthetic lipid‑modified peptide analogue, consisting of a 31‑amino‑acid backbone with a covalently attached C18 fatty di‑acid side‑chain via a hydrophilic spacer. It shares 94% amino‑acid sequence homology with native human GLP‑1 peptide. The substance appears as white to almost white hygroscopic powder, with molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and molecular weight of 4113.58 g/mol. Structural modifications grant it resistance against DPP‑4 enzymatic degradation and enable reversible binding to serum albumin, contributing to its extended in‑vivo half‑life property.

Basic Info

Product Name:

Semaglutide

Other Name:

Sermaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;semaglutide;Sermaglutide CAS 910463 68 2;Semaglutide (H-7894.0001);semgalutide;Semaglutide Injection

CAS No.:

910463-68-2

Molecular Formula:

C187H291N45O59

InChIKeys:

DLSWIYLPEUIQAV-CCUURXOWSA-N

Molecular Weight:

4113.57754

Exact Mass:

4113.122087 g/mol

EC Number:

203-405-2

Color/Form:

White to off-white

Categories:

Other Chemical Drugs

Characteristics

PSA:

1650 Å²

XLogP3:

5.44520

Critical Temperature & Pressure:

Store at -20°C

Research

Class:

GLP-1R agonist

Status:

FDA-approved (Ozempic / Wegovy / Rybelsus)

Mechanism:

Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.

Activity note:

Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).

Source:

Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI

Clinical Development:

NCT03548935; NCT03552757; NCT01720446; NCT02692716

FDA:

Ozempic, Wegovy, Rybelsus (approved 2017-12-05)

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)

Disclaimer:

Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.

See More Semaglutide Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Semaglutide Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Functional Food Ingredients (Chondroitin sulfate),3,5-di-tert-butylsalicylic acid,TBPB,Cosmetic Ingredients(PDRN&PN, EGT,HA, Ectoine),API & Intermediates(Semaglutide&related products),Agrochemicals

Location:
Rm333-3F,1st building,No.59 Tianyuan West Road,Jiangning,NANJING CHINA

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
14

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2017

First Rays Co.,Ltd is a scientific and innovative company focusing on R&D,manufacturing and sales of chemical materials. Our company introduced top-notch high-tech from home and abroad to support product innovation. We also established long-term and stable cooperative relations with hundreds of Chinese qualified manufactures. At present, our company's products cover agrochemicals, fine chemicals, APIs&intermediates,cosmetics ingredients, functional ingredients, etc. Our main products include 3,5-di-tert-butylsalicylic acid,Semaglutide&related intermediates,PDRN&PN, Ergothioneine, Ectoine,Hyaluronic acid series (various molecular weight hyaluronic acid and modified hyaluronic acid, etc.), Recombinant humanized collagen (type Ⅲ), Small molecular weight chondroitin sulfate(food grade).
With a commitment to quality and customer satisfaction,First Rays Co.,Ltd has become a reliable supplier of chemical products on the echemi.com.

Inquiry History

493 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Weight Loss Semaglutide intermediate 99% White powder COA High Quality peptide GLP-1 910463-68-2	5 MG	Apr 11, 2024
United States	Gene-Biocon Semaglutide 910463-68-2 GLP-1analogs diabetes weight loss 96% White or off-white powder	2	Dec 5, 2023
United States	Semaglutide 910463-68-2	1 G	Sep 21, 2023
United States	Sermaglutide 99% 910463-68-2	2 KG	Oct 21, 2023
China	Semaglutide CAS 910463-68-2	1 KG	Apr 16, 2026
United Kingdom	TGYFactory Supply Semaglutide Peptide 99% CAS 910463-68-2	50 MT	Nov 13, 2023
Sri Lanka	Bulk Supply 98% up Sermaglutide powder CAS 910463-68-2	300 G	Nov 18, 2023
United States	Semaglutide Ozempic Sermaglutide 99.9% white powder 910463-68-2 Teruiop	500 G	Oct 9, 2023
United States	Raw mateiral Semaglutide CAS 910463-68-2 99% White powder	1000 G	Sep 23, 2023
Switzerland	Semaglutide Ozempic Sermaglutide 99.9% white powder 910463-68-2 Teruiop	5000 MT	Sep 13, 2023
United States	High Purity Peptide Semaglutide 910463-68-2 With Safe Shipping	1 G	Sep 7, 2023
United States	10MG vial pack Semaglutide 99% 910463-68-2 GLP-1 Peptide	10 MT	Oct 18, 2023
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	60 MG	Aug 4, 2025
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	10 MT	Sep 19, 2025
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	2	Nov 13, 2024
United States	semaglutide CAS 910463-68-2 in stock 2-4 days safe delivery	1 MT	Nov 4, 2023
United Kingdom	API Pharmaceutical Chemical Grade Raw Materials CAS 910463-68-2 Semaglutide	40 MT	Sep 27, 2023
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	10	Sep 27, 2023
China	Semaglutide Tirzepatide for Weight Loss CAS: 910463-68-2 Retatrutide Cagrilintide	1 MT	Jul 5, 2025
India	Best Price 99% Semaglutide Peptide 10mg Vials Semaglutide CAS 910463-68-2	100	Nov 8, 2023

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