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semaglutide side chain tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu senwayer

Name: semaglutide side chain tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu senwayer
Brand: Senwayer
SKU: pr2308241503
Price: 1000 USD
Availability: InStock

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CAS No.:

1118767-16-0

Grade:

Pharmaceutical Grade

Content:

40%

Port:

wuhan

Brand:

Senwayer

Packaging:

bag

Sample Available:

Yes

Price valid (until):

2023-09-24

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Product Introduction

tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is a glucagon-like peptide-1 analog.

Product name	tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
CAS No.	1118767-16-0
MF	C43H79N3O13
MW	846.1
Melting point	N/A
EINECS No.	N/A
Boiling point	940.6±65.0 °C(Predicted)
Density	1.079±0.06 g/cm3(Predicted)
Storage	N/A
Solubility	N/A

About us

Wuhan senwayer century chemical Co.,Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.

We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.

With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

If you are interested, pls contact me freely!

ECHEMI Editorial Reference

tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is the 18-carbon fatty acid side chain of somatostatin, which contributes to an increased affinity for albumin (approximately 5-6 fold). Somalutide is a glucagon-like peptide-1 (GLP-1) analogue with hypoglycaemic properties.
TBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is also known as Semaglutide Side Chain. An 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy.
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, as the side chain of semaglutide, can be used in the solid-phase and semi-synthetic recombinant fermentation process of semaglutide.

Certificates

Basic Info

Product Name:

tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu

Other Name:

(S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid;Octadecane(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH;Side chain;tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu;Semaglutide side chain;Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OHu;(S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid;Egf(a) analogue-13C4

CAS No.:

1118767-16-0

Molecular Formula:

C43H79N3O13

InChIKeys:

YZUXNRZPWYRMGH-DHUJRADRSA-N

Molecular Weight:

846.1

Color/Form:

White to off-white

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.079±0.06 g/cm3(Predicted)

Boiling Point:

940.6±65.0 °C(Predicted)

PKA:

3.39±0.10(Predicted)

Critical Temperature & Pressure:

Keep in dark place, Sealed in dry, Store in freezer, under -20°C

Research

Class:

GLP-1R agonist

Status:

FDA-approved (Ozempic / Wegovy / Rybelsus)

Mechanism:

Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.

Activity note:

Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).

Source:

Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI

Clinical Development:

NCT03548935; NCT03552757; NCT01720446; NCT02692716

FDA:

Ozempic, Wegovy, Rybelsus (approved 2017-12-05)

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)

Disclaimer:

Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu	10 KG	May 7, 2025
India	(tBu-OOC-C16-CO-Glu(AEEA-AEEA)-OtBu)-OSU	1 KG	Mar 2, 2024

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semaglutide side chain tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu senwayer

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