3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside/ Diosmin CAS NO. 520-27-4

Diosmin Description :                                                                                            

Diosmin is a semisynthetic flavonoid molecular derived from Citrus d ( Modified Hesperidin ).

Diosmin is used for treating various disorders of blood vessels including hemorrhoids ,Varicose veins,poor circulaion in the legs ( venous stasis ),and bleeding(hemorrhage) in the eye or gums .it is also used to treat swelling of the arms( lymphedema) following breast cancer sugery , and to protect against liver toxicity .it is often taken in combination with hesperidin. Diosmin is currently a prescription medication, and is also sold as a nutritional supplement.

High assay: 90%,95% For EP standard

Impuirty Control: Total impurities less than 4.0%

Low Pesticide Residue

Solvents Free

Diosmin + Hesperidin 90:10

It is the mixture of Diosmin and Hesperidin ,Which is widely used for pharmaceutical and food supplement.

Application

Diosmin is largely used in EU as a medicine in combination with Hesperidine. The formulation of Dismin 90%+Hesperidin 10% branded Alvenor by famous Servier has an annual sales of millions of dollars in EU. But FDA does not approve it as a medicine but a dietary supplement. Recently a new formulation of Diosmin 95%+Hesperidin 5% has been also approved by EU countries and FDA.

Nowadays more companies in other countries also launched similar products as the same proportion of Diosmin and Hesperidine, whatever it is used as a medicine or dietary supplement, Diosmin has been well acknowledged to be a vascular-protecting agent used to treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins.

Pharmacological effects

1.Diosmin has a specific affinity for the venous system and enhances the tension of the vein without affecting the arterial system

2.Diosmin can reduce the viscosity of blood and increase the flow rate to reduce stasis to the microcirculation system;

3.The lymphatic system can enhance the contraction of lymphatic vessels and the speed of lymphatic drainage, speeding up the reflux and reducing edema

4.

4. Micronized Diosmin can increase the contact area and enhance the absorption rate ,make it with a higher bioavailability. It is suitable for acute attacks of various hemorrhoids and hemorrhoids, and it also treat chronic venous insufficiency, such as varicose veins and lower extremity ulcers.



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