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Diosmin

Diosmin structure

CAS No:
520-27-4
Formula:
C28H32O15
Chemical Name:
Diosmin
Synonyms:
4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-;Diosmin;7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;Diosmetin 7-β-rutinoside;3′,5,7-Trihydroxy-4′-methoxyflavone 7-O-rutinoside;Diosmine;Diosmetin 7-rutinoside;Venosmine;Diosmetin 7-O-rhamnosyl(1→6)-glucoside;Insuven;Diosmil;Diovenor;Ven-Detrex;Litosmil;Buchu resin;Hemerven;Flebosten;Barosmin;Varinon;Diosven;Flebosmil;Tovene;Dioven;Venex 500;3′,5-Dihydroxyl-4′-methoxylflavanone-7-O-α-L-rhamnosyl (1→6)-β-D-glucopyranoside;Diosmetin 7-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside;Diosmetin 7-O-rutinoside;Phlebodia;Flebodia;9000-18-4;28680-33-3
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

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Description

Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

Solid

Diosmetin rutinoside is a member of flavonoids and a glycoside.

Diosmin Basic Attributes

Molecular Weight：

608.54500

Exact Mass：

608.54

EC Number：

208-289-7

HScode：

2932999099

Characteristics

PSA：

238.20000

XLogP3：

-0.8

Appearance：

Greyish-yellow or light yellow hygroscopic powder

Density：

1.68 g/cm3

Melting Point：

274 °C (decomp)

Boiling Point：

926.8ºC at 760 mmHg

Flash Point：

305.2ºC

Refractive Index：

1.711

Water Solubility：

Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C).

Storage Conditions：

2-8ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26; S36; S36/37

Marks：

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H341

Diosmin Use and Manufacturing

1. Vascular protectant
2. Naturally occurring flavonic glycoside; rhamnoglycoside of Diosmetin. Capillary protectant

Computed Properties

Molecular Weight:608.5
XLogP3:-0.8
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:7
Exact Mass:608.17412031
Monoisotopic Mass:608.17412031
Topological Polar Surface Area:234
Heavy Atom Count:43
Complexity:995
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Vascular protector and capillary stabilizer, reduces venous distensibility and venous blood stasis, improves capillary wall permeability and enhances its resistance

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diosmin Tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 500 mg of purified micronized flavonoid compounds, including 450 mg of diosmin and 50 mg of flavonoid components expressed in the form of hesperidin. Molecular weight: C28H32O15
Indication	No drug interaction studies have been conducted. However, based on extensive post-marketing experience with this product, no interactions with other drugs have been reported.
Specifications	500mg

Diosmin Tablets
Specifications	500mg

Diosmin Tablets
Ingredients	Diosmin.
Indication	So far, no interactions with other drugs have been found.
Specifications	500 mg

See More Related Drugs

Registered Holders

PMC ISOCHEM

France
Active
Hunan Yuantong Pharmaceutical Co., Ltd.

China
Active
Chengdu Runde Pharmaceutical Co., Ltd.

China
Active

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Guide of Diosmin

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Diosmin

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