China Largest factory Manufacturer Supply High Quality NOOTKATONE CAS 4674-50-4
GMP HALAL KOSHER ISO FDA TDS
4674-50-4
Cosmestic Grade
99%
Shanghai
Leader
25KG/Drum
2023-12-11
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceNootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].
Colourless to pale yellow or orange coloured oily liquid; Powerful fruity sweet, citrusy, grapefruit peel oil like aroma
(+)-nootkatone is a sesquiterpenoid that is 4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one which is substituted by methyl groups at positions 4 and 4a, and by an isopropenyl group at position 6 (the 4R,4aS,6R stereoisomer). It has a role as a plant metabolite, a fragrance and an insect repellent. It is a sesquiterpenoid, an enone and a carbobicyclic compound.
Nootkatone has a pleasant taste. It may be prepared by oxidation of valencene (a sesquiterpene) with tertiary butyl chromate.
(+)-Nootkatone is sesquiterpene ketone originally isolated from grapefruit juice and peel oil with diverse biological activity. It is lethal against ticks, fleas, and mosquitoes with LC50values of 0.0029, 0.0061, and 0.0046% w/v, respectively. Pretreatment of wood with (+)-nootkatone reduces tunnel lengths, feeding, and survival rates inC. formosanustermites. (+)-Nootkatone (10-100 μM) dose-dependently activates AMPKα1 and AMPKα2 in C2C12mouse myoblast lysate containing a substrate peptide. It dose-dependently inhibits platelet aggregation induced by collagen, thrombin , and arachidonic acid when used at concentrations ranging from 10 to 100 μM with almost complete inhibition at the highest concentration.In vivo, (+)-nootkatone (3-30 mg/kg, p.o.) dose-dependently increases the length of tail bleeding time in mice. (+)-Nootkatone (0.1-0.3%, p.o.) dose-dependently reduces body weight and plasma glucose levels in mice fed a high-fat and high-sucrose diet.Certificates-
TDS
Basic Info-
Product Name:
NOOTKATONE
Other Name:NOOTKATONE;(+)-5,6-dimethyl-8-isopropenylbicyclo[4.4.0]dec-1-en-3-one;2(3h)-naphthalenone,;2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, [4R-(4alpha,4aalpha,6beta)]-;2(3H)-Naphthalenone,4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-,[4R-(4.alpha.,4a.alpha.,6.beta.)]-;4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-,[4R-(4.alpha.,4a.alpha.,6.beta.)]-2(3H)-Naphthalenone;NOOTKATONE 98% CRYSTALS;NOOTKATONE DISTILLED 50%
CAS No.:4674-50-4
Molecular Formula:C15H22O
InChIKeys:WTOYNNBCKUYIKC-UHFFFAOYSA-N
Molecular Weight:218.33
Exact Mass:218.33
BRN:4676969
EC Number:225-124-4
UNII:IZ2Y119N4J
TSCA:TSCA listed
DSSTox ID:DTXSID8047050
Color/Form:White to Pale Yellow
HScode:29142990
Categories:
Characteristics-
PSA:
17.07000
XLogP3:3.84
Appearance:Solid
Density:0,997 g/cm3
Melting Point:35-39 °C
Boiling Point:125°C 0,5mm
Flash Point:99°C
Refractive Index:n20/D1.52
Water Solubility:Slightly soluble in ethanol and chloroform. Partly soluble in water.
Storage Conditions:2-8°C
Vapor Pressure:0.003 mm Hg at 25 °C (est)
Vapor Density:>1 (Air = 1)
Specific rotation:Optical rotation: +195.5 deg (c = 1.5 in CHCL3)
Odor:at 100.00 %. grapefruit peel citrus gardenia woody
Taste:Grapefruit taste
Henrys Law Constant:Henry's Law constant = 1.4X10-4 atm-cu m/mole at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 1.5X10-10 cu cm/molec-sec at 25 °C (est)|Ozone reaction rate constant = 2.3X10-17 cu cm/molec-sec at 25 °C (est)
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
5
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
Above 1000
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Year of Establishment:
2014
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Certifications:
Level A of Tax Credit Registration Assessment by Government,Good Product Quality Management Certificate of Shanxi Province,China,Company Trade Union Qualification Certificate,Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina,AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China,FDA
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