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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Salcaprozate Sodium for Sale > Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1
Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1 buy - large image1
Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1 buy - image1
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Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1

TDS 25 Inquiries

Unit Price: Get Latest Price
CAS No.:

203787-91-1

Grade:

Pharmaceutical Grade

Content:

90%

Port:

Shanghai, Beijing or Dalian

Brand:

HANDOM CHEM

Packaging:

100g/Aluminum Foil Bag, 500g/Aluminum Foil Bag or 1kg/Aluminum Foil Bag.

Sample Available:

Yes

Price valid (until):

2023-12-30

Company Type:
Manufactory
Location:
China
Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
15 days
Qualification:
Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Sodium 8-(2-hydroxybenzamido)octanoate, also called sodium N-[8-(2-hydroxybenzoyl)amino]caprylate), the abbreviation is SNAC, which is a synthetic N-acetylated amino acid derivative of amphoteric salicylic acid.
    It is currently the most advanced intestinal permeation enhancer (PEs) and is widely used as a delivery agent for oral pharmaceutical preparations. In 2014, SNAC was applied to oral vitamin B12 (cyanocobalamin/SNAC) and was successfully approved by the FDA.

    Shop Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1-Detailed Image 1

    Test Items
    Specifications Test Methods
    Appearance White or off-white solid Visual
    Identity Meets the requirements H-NMR
    Purity Not less than 90.0% HPLC



    Relevant Substances

    Impurity A Not more than 0.15% HPLC
    Impurity E Not more than 0.15% HPLC
    Impurity G Not more than 0.5% HPLC
    The maximum unknown single impurity Not more than 1.0% HPLC
    Total Impurities Not more than 10.0% HPLC



    Residual Solvents

    Isopropyl alcohol
    Not more than 5000 ppm GC
    Methyl alcohol
    Not more than 5000 ppm GC
    Ethanol
    Not more than 5000 ppm GC
    DMF
    Not more than 880 ppm GC
    Benzene Not more than 2 ppm GC

    Shop Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1-Detailed Image 2

    Application:
    Sodium 8-(2-hydroxybenzamido)octanoate is an oral absorption enhancer with potential as a delivery agent for oral forms of Heparin, Insulin and Semaglutide.


    Sodium 8-(2-hydroxybenzamido)octanoate increases lipophilicity induced by non-covalent macromolecular complexation, thereby increasing passive transcellular penetration of intestinal epithelial cells.

    Mechanism of action of SNAC and Semaglutide:
    When semaglutide tablets disintegrate in the stomach, sodium 8-(2-hydroxybenzamido)octanoate causes an increase in local pH in the stomach through buffering, and the increase in gastric pH reduces the degradation of semaglutide by pepsin.


    On the other hand, sodium 8-(2-hydroxybenzamido)octanoate promotes semaglutide monomerization by changing the polarity of the solution in which the tablet is dissolved, thus weakening hydrophobic interactions that would otherwise promote semaglutide oligomerization. The absorption of semaglutide is mainly due to the indirect effect of sodium 8-(2-hydroxybenzamido)octanoate, which is incorporated into the lipid membrane of gastric cells, allowing semaglutide to pass across cells.

    Shop Sodium 8-(2-hydroxybenzamido)octanoate, CAS No.: 203787-91-1-Detailed Image 3

    Packaging:
    100g/bag, 500g/bag, 1kg/bag or according to the specific requirements from customers.

    Storage Conditions:
    Short-term storage at room temperature; more than three months is best stored at 2-8 degrees Celsius; more than one year is best stored at -20±5 degrees Celsius.


    For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

    Shelf Life:
    24 months if stored in unopened original bags away from heat and moisture.

    ECHEMI Editorial Reference
    Salcaprozate Sodium is the sodium salt form of salcaprozate, an oral absorption promoter. Salcaprozate sodium may be used as a delivery agent to promote the oral absorption of certain macromolecules with poor bioavailability such as insulin and heparin.
    It is a white to off-white crystalline powder, and its solubility in water is approximately 33 mg/mL.
    Salcaprozate Sodium (SNAC) is a synthetic N-acetylated amino-acid derivative of salicylic acid. SNAC is a weak acid that display amphiphilicity and surface activity. It was discovered as part of a screen to identify carrier-based PEs that could “chaperone” poorly permeable payloads across the intestine. This compound is the most extensively tested carrier and the only PE approved in an oral formulation designed to improve oral BA, albeit with a small molecule, cyanocobalamin/SNAC. In other preclinical studies, it also improved intestinal permeation of peptides (salmon calcitonin (sCT) and insulin), along with poorly permeable small molecules (e.g., cromolyn). SNAC was tested in many formats: taste-masked liquids, tablets, and soft gelatin capsules. Similar to C10, SNAC can be blended with the active pharmaceutical ingredient (API) using conventional processes, which makes manufacturing uncoated oral tablet dosage forms economic and relatively easy to scale[1].

    Certificates

    Basic Info
    Product Name:

    Salcaprozate Sodium

    Other Name:

    sodium,8-[(2-hydroxybenzoyl)amino]octanoate;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt;SNAC,sodium 8-[(2-hydroxybenzoyl)amino]octanoate;Salcaprozate sodium;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, sodium salt;2,5-Furandione,3-chlorodihydro-,(7R)-;N-[8-(2-Hydroxybenzoyl)amino]caprylic acid, disodium salt;Chlorotoluron Impurity 3

    CAS No.:

    203787-91-1

    Molecular Formula:

    C15H22NNaO4

    InChIKeys:

    OBKUJEVXEMKQMJ-UHFFFAOYSA-N

    Molecular Weight:

    303.33

    Exact Mass:

    301.12900240

    EC Number:

    231-019-4

    UNII:

    1YTW0422YU

    DSSTox ID:

    DTXSID50174306

    NCI Thesaurus Code:

    C75026

    Color/Form:

    White to Off-White

    Characteristics
    Melting Point:

    183 - 185°C

    Critical Temperature & Pressure:

    Inert atmosphere,Room Temperature

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

    Location:

    RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

    Payment Terms:

    TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    15 days

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    51-100

    Year of Establishment:

    2020

    Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.

  • Inquiry History
    25 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Salcaprozate Sodium

    1 KG Feb 13, 2026
    India

    Salcaprozate sodium

    1 KG May 8, 2024
    Tunisia

    Salcaprozate de sodium (SNAC)

    1 MT May 4, 2026
    India

    Salcaprozate Sodium

    1 KG Jul 20, 2026
    Italy

    Sodium Salcaprozate (SNAC)

    250 G Apr 17, 2026
    Pakistan

    SALCAPROZATE SODIUM SNAC

    450 KG Apr 10, 2026
    United States

    Salcaprozate Sodium

    500 KG Feb 18, 2026
    United States

    Salcaprozate Sodium/ SNAC 99%

    10 KG Feb 13, 2026
    Pakistan

    SALCAPROZATE SODIUM

    500 KG Feb 11, 2026
    Pakistan

    SALCAPROZATE SODIUM

    180 KG Jul 20, 2026
    United Kingdom

    Salcaprozate Sodium

    1 MT Jul 17, 2026
    Pakistan

    SALCAPROZATE SODIUM

    50 KG Jun 5, 2026
    United States

    Salcaprozate Sodium

    50 KG Feb 27, 2026
    Pakistan

    Salcaprozate Sodium

    5 KG Jan 9, 2026
    United States

    Salcaprozate Sodium (SNAC)

    1 KG Nov 24, 2025
    United States

    Salcaprozate sodium 99% white powder wholesale

    100 G Sep 11, 2025
    Pakistan

    Salcaprozate Sodium

    200 KG Mar 6, 2025
    Pakistan

    SALCAPROZATE SODIUM

    3 KG Apr 30, 2024
    Turkey

    Salcaprozate Sodium-GMP

    6 MT Nov 13, 2023
    Pakistan

    SALCAPROZATE SODIUM

    600 KG Jan 28, 2026
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