China Most Professional Manufacturer Supply High Qulity Sylibin/ Silybin / Silybine / Silibinin CAS 22888-70-6
GMP HALAL KOSHER ISO FDA TDS 1 Inquiries
22888-70-6
Pharmaceutical Grade
99%
Shanghai
Leader
25KG/Drum
Yes
2023-12-28
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceSilibinin, an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.IC50 value:Target: anticancerin vitro: silibinin significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines, suggesting that silibinin-induced NAG-1 up-regulation is p53-independent manner.Silibinin up-regulat
Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone.|Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.|The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.Certificates-
![China Most Professional Manufacturer Supply High Qulity Sylibin/ Silybin / Silybine / Silibinin CAS 22888-70-6 Certificates 7]( "TDS")
TDS
Basic Info-
Product Name:
Silybin
Other Name:4H-1-Benzopyran-4-one,2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-;4-Chromanone,3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl]-;Silybin;4H-1-Benzopyran-4-one,2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,[2R-[2α,3β,6(2R*,3R*)]]-;1,4-Benzodioxin,4H-1-benzopyran-4-one deriv.;(2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Silybine;Silymarin I;7C3MT;Silliver;Silymarine I;Silibinin;Silymarin MZ 80;Silybum substance E6;Silybin A;Silybin b1;Silibinin A;Mepasil;Realsil;142796-20-1;11054-49-2;11076-05-4;11076-06-5;22888-69-3;27359-03-1;28577-40-4;29832-10-8;37574-50-8;50976-99-3;87725-90-4
CAS No.:22888-70-6
Molecular Formula:C25H22O10
InChIKeys:InChIKey=SEBFKMXJBCUCAI-HKTJVKLFSA-N
Molecular Weight:482.44
Exact Mass:482.44
EC Number:245-302-5
UNII:33X338MNE4
NSC Number:651520
DSSTox ID:DTXSID5023580|DTXSID8026018
ATC Code:A - Alimentary tract and metabolism
HScode:2932999099
Categories:
Characteristics-
PSA:
155
XLogP3:2.4
Appearance:solid
Density:1.5±0.1 g/cm3
Melting Point:158 °C
Boiling Point:793°C at 760 mmHg
Flash Point:274.5±26.4 °C
Refractive Index:1.684
Water Solubility:54mg/L(24.99 ºC)
Storage Conditions:−20°C
Vapor Pressure:1.63E-26mmHg at 25°C
Toxicity:LD50 intravenous in mouse: 1056mg/kg
Specific rotation:D20 +11° (c = 0.25 in acetone + alcohol)
Collision Cross Section:213.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
5 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
Above 1000
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Year of Establishment:
2014
Company Certificates-
![LEADER BIOCHEMICAL GROUPLevel A of Tax Credit Registration Assessment by Government]( "Level A of Tax Credit Registration Assessment by Government")
Level A of Tax Credit Registration Assessment by Government
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![LEADER BIOCHEMICAL GROUPGood Product Quality Management Certificate of Shanxi Province,China]( "Good Product Quality Management Certificate of Shanxi Province,China")
Good Product Quality Management Certificate of Shanxi Province,China
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![LEADER BIOCHEMICAL GROUPCompany Trade Union Qualification Certificate]( "Company Trade Union Qualification Certificate")
Company Trade Union Qualification Certificate
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![LEADER BIOCHEMICAL GROUPExcellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina]( "Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina")
Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
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![LEADER BIOCHEMICAL GROUPAAA TOP Credit Excellent Group Enterprise of Shanxi Province,China]( "AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China")
AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
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![LEADER BIOCHEMICAL GROUPFDA]( "FDA")
FDA
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
Milk Thistle Extract 80% UV
1.00 MT Jun 29, 2026 Post an enquiry for this product
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