(+)-Griseofulvin in stock
5 Inquiries
126-07-8
Industrial Grade,Pharma Grade
according to the clients requirement
Yes
2024-12-31
N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol
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Product Description
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Seller Information
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Inquiry History
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DescriptionKeywords
(+)-Griseofulvin Manufacturer in China
(+)-Griseofulvin High quality low price in stock
(+)-Griseofulvin Supplier in China
Quick DetailsProName:(+)-Griseofulvin in stock
CasNo:126-07-8
Molecular Formula:C17H17ClO6
Appearance:Detailed see specifications
Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
DeliveryTime:prompt
PackAge:according to the clients requirement
Port:Shanghai
ProductionCapacity:1-10 Metric Ton/Month
Purity:98%
Storage:Store in dry, dark and ventilated place.
Transportation:by sea or by air
LimitNum:1 Kilogram
Heavy metal:10 ppm Max
Grade:Industrial Grade,Pharma Grade
SuperiorityAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis chemicals in lab, plant and industrial scale with more than fifteen years.
DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice.
Pls contact with us freely for getting detailed product specifications, product tech. date sheet, COA and MSDS, prices, delivery time and payment terms.
DetailsDayang Chem (Hangzhou) Co. Limited, established in 2000, dedicated to the development, production and marketing of chemicals. We are a leading manufacturer and supplier of chemicals in China.
Manufacturing base: The Company has some Manufacturing base in Zhejiang, Jiangsu and Shandong provide. These bases focus on production and Contract Manufacturing.
Sales agent: Dayangchem are authorized by many Chinese chemical manufacturers as universal agency and international area agency. Dayangchem has established very good cooperation and business relations with hundreds of Chinese qualified manufacturers by long time business intercourse.
Strong quality control system: Strength of our ethical commitment to quality control and quality assurance systems firmly based on ISO standard. QA and QC used in the whole process of raw material control, process control and finished product quality inspection.
Third lab test: Audit directly and tested by third party like SGS or INTERTEK in any time will be accepted under required.
Flexible payment terms: Various payment terms such as L/C,D/P,D/A and T/T will be accepted. Special Notice: DAYANGCHEM never require customers to remit payment to a personal account. Beware of being cheated.
Rich experience in sales: 1000 square meters of office space with independent property rights, Sales team of nearly 40 people. Our customers throughout the world, especially the world-renowned companies, such as BACHEM, BASF, CELANESE, CORDEN,DOW,EVONIK, GENZYME,HENKEL, MERCK,ROCHE,SANOFI,SOLVAY.
ECHEMI Editorial ReferenceIt is white or white-like powder. Melting point is 218-224 °C. It is highly soluble in tetrachloroethane, soluble in acetone or chloroform, slightly soluble in methanol or ethanol, and very slightly soluble in water. It is odorless or almost odorless with slightly bitter taste. It is stable to heat. Crystalline SolidChEBI: An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not res
Griseofulvin appears as white to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F. (NTP, 1992)|Solid
Griseofulvin appears as white to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F. (NTP, 1992)|Griseofulvin is an oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment. It has a role as an antibacterial agent and a Penicillium metabolite. It is an organochlorine compound, a member of 1-benzofurans, an oxaspiro compound, an antibiotic antifungal drug and a benzofuran antifungal drug.|An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.|Griseofulvin is a Tubulin Inhibiting Agent. The physiologic effect of griseofulvin is by means of Decreased Mitosis, and Microtubule Inhibition.|Griseofulvin is a fungistatic agent used to treat superficial fungal skin infections such as tinea capitis and pedis. Griseofulvin therapy can cause transient mild-to-moderate serum aminotransferase elevations and has very rarely been linked to clinically apparent acute drug induced liver injury.|Griseofulvin is an antifungal agent derived from the mold Penicillium griseofulvum that is used to treat fungal infections of the skin and nails. Griseofulvin binds to tubulin, disrupting microtubule function and inhibiting mitosis.|An antifungal agent used in the treatment of TINEA infections.
Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus.1Inhibits the growth of adrenocortical cancer cellsin vitro.2 Griseofulvin inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content.3
Crystalline SolidBasic Info-
Product Name:
(+)-Griseofulvin
Other Name:7-Chloro-2,4,6-trimethoxy-6-methyl-, (1S-trans)-Spiro(benzofuran-2(3H),1-(2)cyclohexene)-3,4-dione;Grisovi;Griseofulvin, (2S)-trans-7-Chloro-2μ,4,6-trimethoxy-6μ-methylspiro(benzofuran-2[3H],1μ-[2]cyclohexene)-3,4μ-dione;7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;Grisact;(+)-Griseofulvin,97%;GRISEOFULVIN(RG);Griseofulvin (200 mg)
CAS No.:126-07-8
Molecular Formula:C17H17ClO6
InChIKeys:DDUHZTYCFQRHIY-RBHXEPJQSA-N
Molecular Weight:352.77
Exact Mass:352.77
BRN:95226
EC Number:204-767-4
UNII:32HRV3E3D5
NSC Number:755822
DSSTox ID:DTXSID8020674
NCI Thesaurus Code:C65819
Color/Form:White to yellow-white
ATC Code:D - Dermatologicals
HScode:29419090
Categories:
Characteristics-
λmax:
321nm(CHCl3)(lit.)
PSA:71.1
XLogP3:2.2
Appearance:White to yellow-white Powder
Density:1.2579 (rough estimate)
Melting Point:218-220 °C(lit.)
Boiling Point:469.04°C (rough estimate)
Flash Point:228.0±29.1 °C
Refractive Index:1.4429 (estimate)
Water Solubility:practically insoluble
Storage Conditions:−20°C
Vapor Pressure:3.11E-11mmHg at 25°C
Toxicity:Griseofulvin has a relatively low toxicity to warm-blooded animals; intraperitoneal injection of both sexes of Waster rats found that they could both withstand a dosage of per 100ml/kg (some damage effects on the seminal vesicles and the intestinal epithelium were observed). Although intravenous injection can cause the temporary inhibition of cells mitosis (especially bone marrow some cells), the rates were almost unaffected under normal conditions. Moreover, after 24 hours, the rats began to rapidly recover; its LD50 is 400ml/kg body weight. Furthermore, even a large dose of griseofulvin only has a very small toxicity to the plants. It will be slowly degraded in the body with a faster degradation rate in soil; so there are no issues about residue and environmental pollution problems. However, the property of its fast degradation also limits their application of antimicrobial activity in agriculture.
Flammability characteristics:Combustion produces toxic chloride gas
Specific rotation:354 º (c=1, dimethylform)
Odor:ODORLESS
Collision Cross Section:178.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:SUBLIMES WITHOUT DECOMP @ 210 °C
Air and Water Reactions:Insoluble in water.
Reactive Group:Ethers
Reactivity Profile:(+)-Griseofulvin is incompatible with strong oxidizing agents. .
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
Carcinogenicity, Category 2
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H317 May cause an allergic skin reaction
H351 Suspected of causing cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
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Seller Information
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Business Type:
Manufactory
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Main Products:
N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol
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Location:
RM901-7,Unit 2,259# WenSan Road, Xihu District, Hangzhou Zhejiang, China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
2 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2020
Company Certificates-
Dangerous Chemicals Business License
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Pesticide Business License
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ISO 9001:2015
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
Griseofulvin
500 KG Oct 8, 2024
Belgium
Griseofulvin
8 KG Nov 20, 2023
Bangladesh
Griseofulvin BP/EP
1 KG Jul 18, 2024
India
greisofluvin
1 TON Apr 19, 2024
Saudi Arabia
GRISEOFULVIN
1 KG Feb 23, 2024 Post an enquiry for this product
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