5'-Deoxy-5-fluorouridine
3094-09-5
99%
SHANGHAI
25kg/drum
2024-01-04
Diclofenac Acid,Nitrendipine,Propafenone
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceDoxifluridine(Ro 21-9738; 5'-DFUR) is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM. IC50 value: 0.62 μM(PC9-DPE2 cell).Target: Nucleoside antimetabolite/analogDoxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of p
Doxifluridine is a pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. It has a role as an antimetabolite, an antineoplastic agent and a prodrug. It is an organofluorine compound and a pyrimidine 5'-deoxyribonucleoside.|Doxifluridine has been investigated for the treatment of Stomach Cancer.|Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.Basic Info-
Product Name:
Doxifluridine
Other Name:Uridine,5′-deoxy-5-fluoro-;5′-Deoxy-5-fluorouridine;Ro 21-9738;Doxifluridine;5-Fluoro-5′-deoxyuridine;5-Fluorodesoxyuridine;5′-DFUR;Furtulon;5′-dFUrd;Flutron;Fulturon;1226642-64-3
CAS No.:3094-09-5
Molecular Formula:C9H11FN2O5
InChIKeys:InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N
Molecular Weight:246.19
Exact Mass:246.19
EC Number:221-440-1
UNII:V1JK16Y2JP
DSSTox ID:DTXSID2022967
NCI Thesaurus Code:C978
HScode:2934999090
Categories:
Characteristics-
PSA:
99.1
XLogP3:-1.7
Appearance:White Solid
Density:1.6±0.1 g/cm3
Melting Point:190 °C
Refractive Index:1.605
Water Solubility:>36.9 [ug/mL]
Storage Conditions:-20°C Freezer
Toxicity:LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)
Specific rotation:D25 +18.4° (c = 0.419 in water)
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Diclofenac Acid,Nitrendipine,Propafenone
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Location:
NO.6, JINSHAN ROAD, HI-TECH INDUSTRIAL DEVELOPMENGT ZONE,SUZHOU JIANGSU, CHINA
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Payment Terms:
D/P,L/C,D/A
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Average lead Time:
20
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2003
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