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Semaglutide side chain FMOC-L-LYS[OCT-(OTBU)-GLU-(OTBU)-AEEA-AEEA]-OH
5 Inquiries
1662688-20-1
Pharmaceutical Grade
95%
Shanghai or Beijing
HANDOM CHEM
1g/bottle, 5g/bottle or 10g/bottle
Yes
2024-01-07
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceFmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH is a useful research chemical used in the preparation of semaglutide. Reagent grade, for research purpose.Basic Info
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Product Name:
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH
Other Name:Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH;Octa(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH;11,14,20,23-Tetraoxa-2,8,17,26,31-pentaazanonatetracontanedioic acid, 3-carboxy-30-[(1,1-dimethylethoxy)carbonyl]-9,18,27,32-tetraoxo-, 49-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester,;22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid;11,14,20,23-Tetraoxa-2,8,17,26,31-pentaazanonatetracontanedioic acid, 3-carboxy-30-[(1,1-dimethylethoxy)carbonyl]-9,18,27,32-tetraoxo-, 49-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3S,30S)-;Fmoc-Lys-(Octa-OtBu)-Glu(AEEA-AEEA-OH)-OH;(23S,50S)-50-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-23-(tert-butoxycarbonyl)-2,2-dimethyl-4,21,26,35,44-pentaoxo-3,30,33,39,42-pentaoxa-22,27,36,45-tetraazahenpentacontan-51-oic acid;Fmoc-Lys(Oct(otBu)-Glu(otBu)-AEEA-AEEA)-OH
CAS No.:1662688-20-1
Molecular Formula:C64H101N5O16
InChIKeys:COTQASXXEXJBOM-PJYGOTMFSA-N
Molecular Weight:1196.51
Exact Mass:1195.72433215
Color/Form:Colorless to light yellow
Categories:
Characteristics-
Density:
1.130±0.06 g/cm3(Predicted)
Boiling Point:1215.5±65.0 °C(Predicted)
PKA:3.87±0.21(Predicted)
Critical Temperature & Pressure:-20°C
Research-
Class:
GLP-1R agonist
Status:FDA-approved (Ozempic / Wegovy / Rybelsus)
Mechanism:Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.
Activity note:Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).
Source:Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI
Clinical Development:FDA:Ozempic, Wegovy, Rybelsus (approved 2017-12-05)
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Literature:
NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)
Disclaimer:Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine
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Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2020
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted 
Poland
FMOC-L-LYS[OCT-(OTBU)-GLU-(OTBU)-AEEA-AEEA]-OH
10 G Dec 5, 2023 
India
Fmoc-L-Lys-{Octadecanedioic acid(OtBu)- Ƴ-Glu-PEG-PEG-OH}
6 KG Feb 9, 2026
India
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH
1 KG Aug 13, 2025
India
Fmoc-Lys(tBu-OOC-C16-CO-Glu(AEEA-AEEA)-OtBu)-OH
1 KG Mar 2, 2024
Poland
FMOC-L-LYS[OCT-(OTBU)-GLU-(OTBU)-AEEA-AEEA]-OH.
10 G Dec 6, 2023 Post an enquiry for this product
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