China Most Professional Factory Supply High Qulity 27-Hydroxycholesterol CAS 20380-11-4
GMP HALAL KOSHER ISO FDA TDS
20380-11-4
Pharmaceutical Grade
99%
Shanghai
Leader
25KG/Drum
2024-01-10
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceSolid
(25R)-cholest-5-ene-3beta,26-diol is a 26-hydroxycholesterol in which the 25-position has R-configuration. It has a role as an apoptosis inducer, a neuroprotective agent, a human metabolite and a mouse metabolite. It derives from a cholesterol.|27-Hydroxycholesterol is an endogenous metabolite of cholesterol produced by the hydroxylation of the carbon at position 27 by the enzyme sterol 26-hydroxylase, mitochondrial (CYP27A1). Some neoplasms produce excess of 27-hydroxycholesterol (27HC) or inhibit its catabolism, and high cholesterol levels are correlated with elevated levels of 27HC; under these conditions, 27HC may have deleterious selective estrogen receptor modulator (SERM) and liver X receptor (LXR) agonistic activities. As a SERM, 27HC binds to and prevents the activation of estrogen receptors (ERs) in the vasculature. This prevents ER-mediated vasodilation and abrogates the cardiovascular protective effects of estrogen. However, 27HC binds to and activates ERs and LXRs in breast tissue, which stimulates ER-dependent breast cancer cell growth and metastasis.Certificates-
TDS
Basic Info-
Product Name:
(25R)-26-Hydroxycholesterol
Other Name:Cholest-5-ene-3,26-diol,(3β,25R)-;Cholest-5-ene-3β,26-diol,(25R)-;(3β,25R)-Cholest-5-ene-3,26-diol;(25R)-Cholest-5-ene-3β,26-diol;(25R)-26-Hydroxycholesterol;(3β,25R)-Cholest-5-ene-3,26-diol
CAS No.:20380-11-4
Molecular Formula:C27H46O2
InChIKeys:InChIKey=FYHRJWMENCALJY-YSQMORBQSA-N
Molecular Weight:402.65300
Exact Mass:402.65
UNII:6T2NA6P5SQ
NCI Thesaurus Code:C123794
Categories:
Characteristics-
PSA:
40.46000
XLogP3:6.36110
Density:1.03
Melting Point:172-174 °C @ Solvent: Hexane, Ethyl acetate
Boiling Point:517.1ºC at 760 mmHg
Flash Point:215.6ºC
Refractive Index:1.537
Vapor Pressure:7.43E-13mmHg at 25°C
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Seller Information
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Business Type:
Manufactory
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Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
5
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
Above 1000
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Year of Establishment:
2014
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Certifications:
Level A of Tax Credit Registration Assessment by Government,Good Product Quality Management Certificate of Shanxi Province,China,Company Trade Union Qualification Certificate,Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina,AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China,FDA
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