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Dimethyl sulfoxide biological activity
Description Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds. Dimethyl sulfoxide has antifreeze and antibacterial properties [1][2].
Related category
Research Areas >> Infection
Research Areas >> Inflammation/Immunity
Signaling Pathways >> Anti-infection >> Bacteria
Dimethyl sulfoxide is an organic solvent that can be freely miscible with water, lipids and organic solvents. These properties allow special membranes to permeate. The mechanism of DMSO is believed to be a combination of anti-inflammatory effect, nerve block, smooth muscle relaxation and collagen inhibition [2].
reference
[1]. C F Brayton. Dimethyl sulfoxide (DMSO): a review. Cornell Vet. 1986 Jan; 76 (1) : 61-90.

[2]. William F Rawls, et al. Dimethyl sulfoxide (DMSO) as intravesical therapy for interstitial cystitis/bladder pain syndrome: A review. Neurourol Urodyn. 2017 Sep; 36 (7) : 1677-1684.

Physical and chemical properties of dimethyl sulfoxide
Density 1.1± 0.1g /cm3
Boiling point 189.0±9.0 °C at 760 mmHg
Melting point 18.4 °C
Molecular formula C2H6OS
Molecular weight 78.13
Flash point 85.0±0.0 °C
Accurate mass 78.013931
PSA 36.28000
LogP-1.35
Appearance properties Colorless liquid
Vapor density 2.7 (vs air)
Vapor pressure 0.8±0.3 mmHg at 25°C
Refractive index 1.480
Storage condition
1. This product should be sealed in a cool and dry place and kept away from light.

2. This product is packaged in aluminum, plastic or glass bottles. Store in a cool, ventilated and dry place, and store and transport according to the provisions of flammable and toxic substances.

stability
1. Colorless liquid, flammable, almost odorless, with bitter taste. The product is a highly polar organic solvent, can be mixed with water in any proportion, in addition to petroleum ether, can dissolve general organic solvents. At 20℃ can absorb hydrogen chloride 30% (weight); Nitrogen dioxide 30% (weight); Sulfur dioxide 65% (weight). Strong hygroscopic, at 20 ° C, when the relative humidity is 60%, it can absorb 70% of its own weight from the air. The product is a weak oxidizing agent, and the non-aqueous dimethyl sulfoxide is non-corrosive to metals. To iron when hydrated; Metals such as copper are corrosive, but not aluminum. Stable to alkali. Heating in the presence of acid produces a small amount of methyl mercaptan; Formaldehyde; Dimethyl sulfur; Mesylate and other compounds. There is decomposition phenomenon at high temperature, and it can react violently in the case of chlorine, burning in the air and emitting a light blue flame.

Chemical properties: Reduction of dimethyl sulfoxide to methyl sulfide. Oxidized to dimethyl sulfone by strong oxidant;

2. When dimethyl sulfoxide is in contact with acyl chloride such as cyanuryl chloride, benzoyl chloride, acetyl chloride, benzoyl iodide chloride, thionyl chloride, thionyl chloride, phosphorus trichloride, etc., intense exothermic decomposition reaction occurs. It combines with nitric acid to form (CH3)2SO·NHO3. Dimethyl sulfoxide can be regenerated by interaction with barium carbonate. React with concentrated hydroiodic acid to form dimethyl sulfur compound.

3. Dimethyl sulfoxide has water absorption and needs to be dried before use.

Freezing point 18.4℃
Molecular structure
1, molar refractive index: 20.17

2, molar volume (cm3/mol) : 71.0

3. Isotropic specific volume (90.2K) : 182.6

4, surface tension (dyne/cm) : 43.6

5. Polarizability (10-24cm3) : 7.99