Factory Supply High Quality NAD+ 99% powder CAS 53-84-9

Biological activity of coenzyme I
Description NAD+, or nicotinamide adenine dinucleotide, is a coenzyme that transfers hydrogen ions. NAD+ is the oxidized form of NADH.
Related category
Research Areas >> Metabolic diseases
Natural Products >> Sugars and glycosides
Target point
Human Endogenous Metabolite

In vitro studies NAD + is a coenzyme composed of ribosyl nicotinamide 5' -diphosphate, which is linked to adenosine 5' -phosphate by pyrophosphate bonds. NAD + is the oxidized form of NADH [1]. NAD + is widely found in nature and is involved in many enzymatic reactions, in which it is used as an electron carrier by alternating oxidation (NAD +) and reduction (Nadide) [2].
In vivo studies oral NAD + supplements have been used to combat simple fatigue as well as mysterious and energy-consuming disorders such as chronic fatigue syndrome and fibromyalgia [3].
reference
[1]. Viollet, B., et al., Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond), 2012. 122(6): p. 253-70.

[2]. Brandt, U., Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem, 2006. 75: p. 69-92.

[3]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.

Physical and chemical properties of Coenzyme I
Melting point 140-142 ºC
Molecular formula C21H27N7O14P2
Molecular weight 663.425
Exact mass 663.109131
PSA 340.71000
LogP-5.72
Appearance properties White powder
Storage condition
This product should be sealed at 4℃ dry storage.

stability
It has a maximum ultraviolet absorption spectrum at 260 nm, and is transformed into a reduced prototype by accepting a hydrogen atom and an electron from the substrate through various deaminases. E '0=-0.32V. The pyridine ring is then reduced and the reaction can be measured due to the maximum absorption at 340 nm. This reaction can also proceed reversibly. Therefore, NAD+ can be used as a common substrate of various deaminases, but the presence of a small amount of the two dehydrogenases can catalyze the REDOX reaction (electron transfer) between the two substrates.

Computational chemistry
1. Reference value of hydrophobic parameter calculation (XlogP) : -6

2. Number of hydrogen bond donors: 7

3. Number of hydrogen bond receptors: 18

4. Number of rotatable chemical bonds: 11

5. Number of tautomers: 6

6. Topological molecular polar surface area (TPSA) : 321

7. Number of heavy atoms: 44

8, surface charge: 0

9. Complexity: 1120

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenter: 8

12. Number of uncertain atomic stereocentes: 0

13. Determine the number of chemical bond structure centers: 0

14. Number of uncertain chemical bond structure centers: 0

15. Number of covalent bond units: 1

more
1. Properties: White powder. Extremely hygroscopic.

2. Density (g/mL,25/4 ° C) : not determined

3. Relative vapor density (g/mL, air =1) : not determined

4. Melting point (ºC) : 266

5. Boiling point (ºC, atmospheric pressure) : 524

6. Boiling point (ºC,5.2kPa) : not determined

7. Refractive index: not determined

8. Flash point (ºC) : Undetermined

9. Specific rotation (º) : [α]D23-34.8° (C=1, in water)

10. Spontaneous ignition point or ignition temperature (ºC) : not determined

11. Vapor pressure (kPa,25ºC) : not determined

12. Saturated vapor pressure (kPa,60ºC) : not determined

13. Heat of combustion (KJ/mol) : not determined

14. Critical temperature (ºC) : not determined

15. Critical pressure (KPa) : not determined

16. Value of oil-water (octanol/water) distribution coefficient: not determined

17. Upper explosion limit (%,V/V) : not determined

18. Lower explosive limit (%,V/V) : not determined

19. Solubility: soluble in water, insoluble in organic solvents such as acetone.