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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one.

Name: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one.
Brand: Dideu
SKU: pr2312251245
Price: 1 USD
Availability: InStock

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CAS No.:

89-25-8

Grade:

National Grade

Content:

99%

Port:

Shanghai

Brand:

Dideu

Packaging:

1kg/bag

Price valid (until):

2024-01-25

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Shop BIS(HYDROXYMETHYL)TRICYCLO[5.2.1.02,6]DECANE-Detailed Image 1

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A)High quality can be guaranteed.Dideo Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted beforee loading.For regular customers,we accept L/C 180 Days,D/P,D/A payment term.If there is any quality problem after goods arrive.Dideu Industries will do fully payment refund.

B)Best price can be guaranteed.As Dideu industries are integrated pharmaceuticals and chemicals producer,the production cost can be controlled and price will be difinitely more competitive than China trading companies.

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ECHEMI Editorial Reference

Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
1-phenyl-3-methyl-5-pyrazolone appears as white to off-white powder or crystals. (NTP, 1992)|DryPowder
1-phenyl-3-methyl-5-pyrazolone appears as white to off-white powder or crystals. (NTP, 1992)|Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. It has a role as a radical scavenger and an antioxidant.|Edaravone is a free radical scavenger approved in May, 2017 for the treatment of amyotrophic lateral scleorosis (ALS). Clinical studies showed that the treatment attenuated deterioration of the disease when compared to placebo. It has been previously investigated for the treatment of ischemic stroke, reperfusion Injury, and myocardial Infarction as it possesses antioxidant and anti-apoptotic properties. Being a low molecular weight molecule with good water and lipid-soluble properies, it is therapeutically advantageous in crossing the blood-brain barrier to mediate nootropic and neuroprotective effects. Oral formulation of edaravone is currently under development.|Edaravone is a free radical scavenger and neuroprotective agent used for therapy of amyotrophic lateral sclerosis. Edaravone is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent, acute liver injury.|An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.

Basic Info

Product Name:

Edaravone

Other Name:

3H-Pyrazol-3-one,2,4-dihydro-5-methyl-2-phenyl-;2-Pyrazolin-5-one,3-methyl-1-phenyl-;2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one;C.I. Developer 1;Developer Z;1-Phenyl-3-methyl-2-pyrazolin-5-one;1-Phenyl-3-methyl-5-pyrazolone;Norphenazone;3-Methyl-1-phenylpyrazolin-5-one;3-Methyl-1-phenyl-2-pyrazoline-5-one;3-Methyl-1-phenyl-5-pyrazolone;1-Phenyl-3-methyl-5-pyrazolinone;3-Methyl-1-phenyl-2-pyrazolin-5-one;Norantipyrine;MCI 186;Edaravone;1-Phenyl-3-methyl-5-oxopyrazole;5-Methyl-2-phenylpyrazol-3-one;3-Methyl-1-phenylpyrazol-5(4H)-one;Radicut;3-Methyl-1-phenyl-4,5-dihydropyrazol-5-one;NSC 12;Methylphenylpyrazolone;NSC 26139;NCI-C 03952;NSC 2629;Edarabone;3-Methyl-1-phenyl-1H-pyrazol-5-one;3-Methyl-1-phenyl-4,5-dihydropyrazole-5-one;1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one;5-Methyl-2-phenyl-2H-pyrazol-3(4H)-one;3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one;5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one;3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one;Phenylmethyl pyrazolone;Radicava;4,5-Dihydro-3-methyl-5-oxo-1-phenylpyrazole;Edvaradone;3-Methyl-1-phenylpyrazole-5-one;5-Methyl-2-phenyl-2,4-dihydropyrazol-3-one;Edaravon;115566-83-1;12235-58-4;52224-17-6;62495-97-0;72134-66-8;206195-95-1

CAS No.:

89-25-8

Molecular Formula:

C10H10N2O

InChIKeys:

InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N

Molecular Weight:

174.19900

Exact Mass:

174.20

EC Number:

201-891-0

NSC Number:

758622|26139|2629|12

DSSTox ID:

DTXSID9021130

Color/Form:

MONOCLINIC PRISMS FROM WATER|WHITE POWDER OR CRYSTALS

ATC Code:

N - Nervous system

HScode:

2933199090

Categories:

Ketones

Characteristics

PSA:

32.67000

XLogP3:

1.3

Appearance:

1-phenyl-3-methyl-5-pyrazolone appears as white to off-white powder or crystals. (NTP, 1992)

Density:

1.12

Melting Point:

127 °C

Boiling Point:

287 °C @ Press: 105 Torr

Flash Point:

155.2ºC

Refractive Index:

1.606

Water Solubility:

H2O: 3 g/L (20 ºC)

Storage Conditions:

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protect

Vapor Pressure:

less than 0.01 mm Hg at 68 °F (NTP, 1992)

Toxicity:

LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79

PKA:

7None

Dissociation Constants:

7.0

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Amides and Imides

Reactivity Profile:

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

See More Edaravone Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Skin sensitization, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H317 May cause an allergic skin reaction H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Edaravone Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

Certifications:
ISO Certificate,REACH

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Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Vietnam	Hair dye intermediates	1000 KG	Dec 4, 2024
Bangladesh	Butyl Acetate	1.00 KG	Nov 11, 2025

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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one.

Product Description

Seller Information