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Promethazine hydrochloride 58-33-3

11 Inquiries

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CAS No.:

58-33-3

Content:

99%

Port:

Chinese seaport

Packaging:

25kg/drum

Price valid (until):

2024-02-02

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Sinoway Industrial Co., Ltd.

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Semaglutide,APIs,Alpha GPC,Liraglutide,Herbal Extract,Nervonic Acid

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Product Description
Seller Information
Inquiry History

Description

Product Detail

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Items

Specifications

Appearance	White to off white Crystalline powder	Conforms
Identification	IR Identical	Conforms
	HPLC Identical	Conforms
	Sulfate Identical	Conforms
Water	N.M.T. 1.0%	0.14%
Residue on Ignition	N.M.T. 0.2%	0.1%
Heavy Metals	N.M.T. 0.002%	Conforms

Basic Info

Product Name:

Promethazine hydrochloride

Other Name:

10H-Phenothiazine-10-ethanamine,N,N,α-trimethyl-,hydrochloride (1:1);Phenothiazine,10-[2-(dimethylamino)propyl]-,monohydrochloride;10H-Phenothiazine-10-ethanamine,N,N,α-trimethyl-,monohydrochloride;10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride;Plletia;Promethazine hydrochloride;Phenergan;Promethazine chloride;Promethazine monohydrochloride;Atosil;Fenergan;Diprazin;Pipolfen;Diprasine;Romergan;Pipolphen;Romergan hydrochloride;Kinetosin;Pyrethia;Promethazinium chloride;Phena;Promasun;Hiberna;Phencen;Dorme;Phenergan VC;Fellozine;Remsed;Lergigan;Genphen;Prorex;Fenazil;Anergan 25;Anergan 50;Duplamin;Prothazine;Mepergan;Provigan;Phanergan D;NSC 231688;Himazin;16639-38-6;88208-28-0

CAS No.:

58-33-3

Molecular Formula:

C17H20N2S.ClH

InChIKeys:

InChIKey=XXPDBLUZJRXNNZ-UHFFFAOYSA-N

Molecular Weight:

320.88

Exact Mass:

320.111389

EC Number:

200-375-2

NSC Number:

757301|231688

DSSTox ID:

DTXSID3021192

HScode:

2933699090

Categories:

Respiratory Drugs

Characteristics

PSA:

31.8

XLogP3:

5.10640

Appearance:

Promethazine hydrochloride is an odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0. (NTP, 1992)

Density:

1.131 g/cm3

Melting Point:

230-232 °C

Boiling Point:

403.7ºC at 760 mmHg

Flash Point:

9℃

Water Solubility:

In water, 1.56X10-2 g/L (15.6 mg/L) at 24 deg C

Storage Conditions:

Refrigerator

Vapor Pressure:

1.03X10-5 mm Hg at 25 deg C (est)

Toxicity:

LD50 i.v. in mice: 55.0 mg/kg (Rajsner)

Collision Cross Section:

162.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Air and Water Reactions:

Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

PROMETHAZINE HYDROCHLORIDE is sensitive to light. In aqueous solution, it is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation (NTP, 1992).

See More Promethazine hydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Skin sensitization, Category 1

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity â single exposure, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Promethazine hydrochloride preparations should be protected from light. Promethazine hydrochloride oral solution and tablets should be stored in tight, light-resistant containers at 15-30 and 20-25 deg C, respectively, while the rectal suppositories should be stored in well-closed containers at 2-8 deg C. Freezing of the oral solution should be avoided. Following the date of manufacture, commercially available promethazine preparations have expiration dates of 2-5 years depending on the dosage form and manufacturer.

See More Promethazine hydrochloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Semaglutide,APIs,Alpha GPC,Liraglutide,Herbal Extract,Nervonic Acid

Location:
16/F.,HUICHENG COMM.COMPLEX, 839 XIAHE RD.,XIAMEN,CHINA

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
1996

Certifications:
ISO9001,Kosher,Halal

Company Profile
   Sinoway Industrial Co., Ltd. was established in China in 1987, and now has grown as a leading company specializing in exporting, custom development and manufacturing of APIs, pharmaceutical intermediates, food supplement ingredients , cosmetic raw materials, including peptide series, prostaglandin series, plant extracts, etc, and pharmaceutical packaging products, including packaging for cold chain, metered-dose inhalation aerosol, etc.
Sinoway has passed ISO9001:2015 and SGS audit to ensure the quality of products and services meet international standards and customers' requirements.
Sinoway also can provide one-stop CDMO service from R&D to production, especially for custom development and manufacturing of advanced intermediates and new compounds with special high quality requirements after signing secret agreements.
Sinoway has established long-term cooperation with China's top analysis&testing centers, institutes and universities, which are equipped with various facilities for special chemical reactions and testing conditions, including HPLC, LC-MS, GC, GCMS, UV, etc., to provide you various testing services for products throughout the entire product development cycle.
Additionally, Sinoway  cooperates closely with Chinese factories, which have advanced production equipments and experts with rich experience in organic chemistry, enzyme catalysis, fermentation processes, etc. They strictly comply with both Chinese and international GMP regulation and ICH Q7 quality management specification.

  Sinoway has a professional sales team with rich experience in products and markets. Since 1992, Sinoway participated in healthcare exhibitions every year, such as CPhI Worldwide, CPhI Japan, CPhI China, and Supply Side West in USA, etc. Sinoway has established long-term business relationships with customers from USA, Canada, Japan, South Korea, Switzerland, Germany , Hong Kong, and others for over 30 years. Sinoway is a reliable supplier of world's leading pharmaceutical companies, such as Novartis, TEVA, Daito, and Sumitomo seika, etc. Besides, Sinoway is the China office of FISCHER Chemical A.G, responsible for project and supply chain services.
"Integrity, Dedication, Gratitude, Innovation, Diligence" is the core values of Sinoway. Sinoway will keep devoting to the supply of custom development&manufacturing of high-quality products with competitive price, and aims to create sustainable values for our customers, shareholders and employees, to maximize values for all customers with high-quality products and professional service, to become one of leading suppliers in big-health industry.

Inquiry History

11 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Hot Selling CAS 58-33-3 Promethazine hydrochloride with 99% Purity White Powder	1 MT	Nov 6, 2023
United States	Promethazine	1 KG	Jan 5, 2026
United States	USA UK Canada Europe etc 99% Pure Promethazine HCl Hydrochloride Powder CAS 58- 33-3 Safe Shipping	1 KG	Dec 14, 2025
Netherlands	Promethazine HCl	100 G	Mar 11, 2025
India	Promethazine Hydrochloride	25 G	Oct 9, 2024
United States	Promethazine HCl	1	Jun 3, 2025
Canada	Promethazine hcl	1 KG	Jan 2, 2024
Argentina	Promethazine hydrochloride	50 G	Apr 15, 2026
United Kingdom	Promethazine HCL 99.9% powder	1	Jan 10, 2026
United States	Promethazine Hydrochloride	20 G	Apr 10, 2025
Kenya	promethazine Hcl	40 KG	Dec 3, 2024

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