China Most Professional factory Supply High Quality 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil CAS 69123-94-0
GMP HALAL KOSHER ISO FDA TDS
69123-94-0
Pharmaceutical Grade
99%
Shanghai
Leader
25KG/Drum
Yes
2024-02-21
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceColourless solid
2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma, among others.|2'-F-ara-deoxyuridine is a deoxyuridine prodrug with potential antineoplastic activity. Upon cellular uptake, 2'-F-ara-deoxyuridine (FAU) is phosphorylated by thymidine kinase to FAU monophosphate and subsequently methylated in the 5'-position by thymidylate synthase (TS) to its activated form, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) 5-methyluracil monophosphate (FMAUMP). FMAUMP is incorporated into DNA leading to an inhibition of DNA synthesis and so cell growth. The catalytic activity of TS is critical to activation of FAU and subsequent incorporation into DNA. FAU may be beneficial in the case of tumors with high TS activity that are resistant to TS inhibitors.Certificates-
TDS
Basic Info-
Product Name:
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
Other Name:2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione;NUK-7;1190089-69-0
CAS No.:69123-94-0
Molecular Formula:C9H11FN2O5
InChIKeys:InChIKey=UIYWFOZZIZEEKJ-PXBUCIJWSA-N
Molecular Weight:246.19
Exact Mass:246.19
UNII:K7386OMP29
DSSTox ID:DTXSID20219192
NCI Thesaurus Code:C80036
HScode:2934999090
Categories:
Characteristics-
PSA:
99.1
XLogP3:-1.31
Appearance:Colourless solid
Density:1.6±0.1 g/cm3
Melting Point:161-162 °C @ Solvent: Chloroform, Methanol
Refractive Index:1.608
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients
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Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
5 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
Above 1000
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Year of Establishment:
2014
Company Certificates-
Level A of Tax Credit Registration Assessment by Government
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Good Product Quality Management Certificate of Shanxi Province,China
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Company Trade Union Qualification Certificate
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Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
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AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
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FDA
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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