1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
-
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
structure -
-
CAS No:
69123-94-0
-
Formula:
C9H11FN2O5
-
Chemical Name:
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
-
Synonyms:
2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione;NUK-7;1190089-69-0
- Categories:
-
CAS No:
Description
Colourless solid
2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma, among others.|2'-F-ara-deoxyuridine is a deoxyuridine prodrug with potential antineoplastic activity. Upon cellular uptake, 2'-F-ara-deoxyuridine (FAU) is phosphorylated by thymidine kinase to FAU monophosphate and subsequently methylated in the 5'-position by thymidylate synthase (TS) to its activated form, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) 5-methyluracil monophosphate (FMAUMP). FMAUMP is incorporated into DNA leading to an inhibition of DNA synthesis and so cell growth. The catalytic activity of TS is critical to activation of FAU and subsequent incorporation into DNA. FAU may be beneficial in the case of tumors with high TS activity that are resistant to TS inhibitors.
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione Basic Attributes
246.19
246.19
K7386OMP29
DTXSID20219192
C80036
2934999090
Characteristics
99.1
-1.31
Colourless solid
1.6±0.1 g/cm3
161-162 °C @ Solvent: Chloroform, Methanol
1.608
Drug Information
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS). (See all compounds classified as Growth Inhibitors.)
2'-fluoro-5-ethyl-1-beta-D-ara U
Computed Properties
Molecular Weight:246.19
XLogP3:-1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:246.06519962
Monoisotopic Mass:246.06519962
Topological Polar Surface Area:99.1
Heavy Atom Count:17
Complexity:374
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
-
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 69123-94-0Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
4 YRS
Business licensedTrader Supplier of vitaminInquiryCAS No.: 69123-94-0Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
5'-deoxy-5'-thioinosine 5'-monophosphate
21959-63-7
-
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone
22003-30-1
-
5'-azacytidine5'-monophosphate
2226-72-4
-
Decarboxylated AdoMet Formula
22365-13-5
-
2′-Deoxy-6-thioinosine Formula
2239-64-7
-
2,2'-Anhydro-5-methyluridine Formula
22423-26-3
-
Quercetin 3-glucuronide Structure
22688-79-5
-
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one Structure
22882-02-6
-
What is Sucrose
57-50-1
-
What is C18Dihydroceramide
2304-80-5
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
SDSRequest for Quotation