Tirofiban
ISO
144494-65-5
pharmaceutical grade
98%
25kg/Cardboard Drum
2024-05-09
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceChEBI: A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-y )butyl group.Tirofiban is a nonpeptide that appears unrelatedchemically to eptifibatide, but actually has many similarities.The chemical architecture incorporates a systemthat is mimicking the RGD moiety that is present in eptifibatide.This can be see
Solid
Tirofiban is a member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. It has a role as a fibrin modulating drug, a platelet glycoprotein-IIb/IIIa receptor antagonist and an anticoagulant. It is a member of piperidines, a sulfonamide and a L-tyrosine derivative.|Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.|Tirofiban is a Platelet Aggregation Inhibitor. The physiologic effect of tirofiban is by means of Decreased Platelet Aggregation.|Tirofiban is a non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time.|Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.CertificatesBasic Info-
Product Name:
Tirofiban
Other Name:L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-;N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine;Tirofiban;Aggrestat;151065-53-1
CAS No.:144494-65-5
Molecular Formula:C22H36N2O5S
InChIKeys:InChIKey=COKMIXFXJJXBQG-NRFANRHFSA-N
Molecular Weight:440.6
Exact Mass:440.60
EC Number:1806241-263-5
UNII:GGX234SI5H
DSSTox ID:DTXSID20162730
NCI Thesaurus Code:C76405
Color/Form:White solid
ATC Code:B01AC17|B - Blood and blood forming organs
HScode:2942000000
Categories:
Characteristics-
PSA:
113
XLogP3:1.4
Appearance:Solid
Density:1.154±0.06 g/cm3(Predicted)
Melting Point:223-225 °C
Boiling Point:611.7±65.0 °C(Predicted)
Flash Point:323.7±34.3 °C
Refractive Index:1.532
Water Solubility:H2O: Very slightly soluble
Vapor Pressure:5.2X10-16 mmHg at 25 deg C /Estimated/
Henrys Law Constant:Henry's Law constant = 7.4X10-15 atm-cu m/mole at 25 °C /Estimated/
Dissociation Constants:pKa = 3.3 (carboxylic acid); pKa = 10.5 (amine) /Estimated/
Experimental Properties:White to off-white, non-hygroscopic, free-flowing powder; MW: 495.08; very slightly soluble in water. /Tirofiban hydrochloride salt mono hydrate/|Hydroxyl radical reaction rate constant = 1.6X10-10 cu cm/molec-sec at 25 °C /Estimated/
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Location:
Room 507, Dongnan Technology R&D Center, No.438 Jincheng Road, Beigan Street, Xiaoshan District,Hangzhou City,Zhengjiang Province,China
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
20
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
51-100
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Year of Establishment:
2013
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Country Product Purchase Quantity Date Posted Post an enquiry for this product






