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Methotrexate 59-05-2

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CAS No.:

59-05-2

Port:

Shanghai

Packaging:

as required

Price valid (until):

2023-11-07

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Hefei Heyu Chemical New Materials Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

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Product Description
Seller Information
Inquiry History

Description

Product Detail

This drug is a folic acid antagonist, the only difference with folic acid is that the hydrogen on the NH on N10 is changed to methyl (CH3), and the C4 ketone group on the ring is changed to amino (NH2), so it can compete with folic acid for the same enzyme, and it is an antimetabolic therapy drug that can prevent (uracil) from transferring a methyl group through folic acid to form (thymine), which is an antitumour drug, or a drug that prevents transplantation from reacting to the host (rejection). It can suppress bone marrow activity and cause hepatitis. It was used in the 1950s when methotrexate was introduced to replace the more toxic antifolate Aminopterin. It was originally synthesised by Yellapragada Subbarao, an Indian biochemist who spent most of his career in the United States, and clinically developed by Sidney Farber, an American paediatrician. This is a drug on the World Health Organisation's Essential Medicines List, the most important list of medicines that are required in the primary health care system. It is one of the most important anti-rheumatoid arthritis (RA) medications, also known as disease-modifying antirheumatic drugs (DMARDs), because it reduces the inflammatory activity of some of the white blood cells (antibodies), further slowing down the damage to bones. Bone damage. This drug should only be used by physicians with knowledge and experience in antimetabolic therapy. Deaths have been reported with high doses in the treatment of malignant diseases.

Basic Info

Product Name:

Methotrexate

Other Name:

METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe

CAS No.:

59-05-2

Molecular Formula:

C20H22N8O5

InChIKeys:

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Molecular Weight:

454.44

Exact Mass:

454.44

BRN:

70669

EC Number:

200-413-8

UNII:

YL5FZ2Y5U1

NSC Number:

740

UN Number:

3249

TSCA:

TSCA listed

DSSTox ID:

DTXSID4020822

NCI Thesaurus Code:

C642

Color/Form:

Light yellow to yellow

ATC Code:

L04AX03|L01BA01|L - Antineoplastic and immunomodulating agents

HScode:

29335995

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

211

XLogP3:

-1.8

Appearance:

powder

Density:

1.4080 (rough estimate)

Melting Point:

195°C

Boiling Point:

561.26°C (rough estimate)

Flash Point:

11℃

Refractive Index:

1.6910 (estimate)

Water Solubility:

Insoluble. <0.1 g/100 mL at 19 ºC

Storage Conditions:

−20°C

Vapor Pressure:

2.1X10-19 mm Hg at 25 deg C /Estimated/

Toxicity:

LD50 oral in rat: 135mg/kg

Specific rotation:

Specific optical rotation: 20.4 + or - 0.6 deg at 21 °C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide)

PKA:

pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

Henrys Law Constant:

Henry's Law constant = 1.5X10-31 atm-cu m/mol at 25 °C /Estimated/

Dissociation Constants:

4.7|pKa = 4.70 (carboxylic acid)|pKa = 3.5 carboxylic acid; pKa2 = 8.8, pKa3 = 9.2 (amines) /Estimated/

Collision Cross Section:

196.2 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|194.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Yellow crystals from dilute hydrogen chloride; decomp 185-204 °C (bath preheated to 160 °C). Max absorption (0.1 n hydrogen chloride): 244, 307 nm; max absorption (0.1 N sodium hydroxide): 257, 302, 370 nm; soluble in alkaline solns with decomposition /Methotrexate monohydrate/|Yellow powder; soluble in water. /Methotrexate sodium/|Hydroxyl radical reaction rate constant = 3.2X10-10 cu cm/molec-sec at 25 °C /Estimated/

Air and Water Reactions:

Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water.

Reactive Group:

Acids, Carboxylic

Reactivity Profile:

Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.

Critical Temperature & Pressure:

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

See More Methotrexate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 deg C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 deg C. Methotrexate sodium

See More Methotrexate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

Location:
Room 1623,Building A, ZhongqiaoCenter,Goverment District,Hefei city,Anhui Province,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2019

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	METHOTREXATE IP/BP/USP	1.00 KG	Jul 4, 2025
India	Methotrexate	1.00 KG	Dec 11, 2023

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