Methotrexate
2 Inquiries
59-05-2
99%
Bottle,barrel,cargo,container,etc.
2026-08-12
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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Inquiry History
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DescriptionKeywords
Methotrexate
59-05-2
C20H22N8O5
Quick DetailsProName:Methotrexate
CasNo:59-05-2
Molecular Formula:C20H22N8O5
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsBasic Info-
Product Name:
Methotrexate
Other Name:METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe
CAS No.:59-05-2
Molecular Formula:C20H22N8O5
InChIKeys:FBOZXECLQNJBKD-ZDUSSCGKSA-N
Molecular Weight:454.44
Exact Mass:454.44
BRN:70669
EC Number:200-413-8
UNII:YL5FZ2Y5U1
NSC Number:740
UN Number:3249
TSCA:TSCA listed
DSSTox ID:DTXSID4020822
NCI Thesaurus Code:C642
Color/Form:Light yellow to yellow
ATC Code:L04AX03|L01BA01|L - Antineoplastic and immunomodulating agents
HScode:29335995
Categories:
Characteristics-
PSA:
211
XLogP3:-1.8
Appearance:powder
Density:1.4080 (rough estimate)
Melting Point:195°C
Boiling Point:561.26°C (rough estimate)
Flash Point:11℃
Refractive Index:1.6910 (estimate)
Water Solubility:Insoluble. <0.1 g/100 mL at 19 ºC
Storage Conditions:−20°C
Vapor Pressure:2.1X10-19 mm Hg at 25 deg C /Estimated/
Toxicity:LD50 oral in rat: 135mg/kg
Specific rotation:Specific optical rotation: 20.4 + or - 0.6 deg at 21 °C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide)
PKA:pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
Henrys Law Constant:Henry's Law constant = 1.5X10-31 atm-cu m/mol at 25 °C /Estimated/
Dissociation Constants:4.7|pKa = 4.70 (carboxylic acid)|pKa = 3.5 carboxylic acid; pKa2 = 8.8, pKa3 = 9.2 (amines) /Estimated/
Collision Cross Section:196.2 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|194.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Yellow crystals from dilute hydrogen chloride; decomp 185-204 °C (bath preheated to 160 °C). Max absorption (0.1 n hydrogen chloride): 244, 307 nm; max absorption (0.1 N sodium hydroxide): 257, 302, 370 nm; soluble in alkaline solns with decomposition /Methotrexate monohydrate/|Yellow powder; soluble in water. /Methotrexate sodium/|Hydroxyl radical reaction rate constant = 3.2X10-10 cu cm/molec-sec at 25 °C /Estimated/
Air and Water Reactions:Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water.
Reactive Group:Acids, Carboxylic
Reactivity Profile:Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.
Critical Temperature & Pressure:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 deg C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 deg C. Methotrexate sodium
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
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Certifications:
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
India
METHOTREXATE IP/BP/USP
1.00 KG Jul 4, 2025
India
Methotrexate
1.00 KG Dec 11, 2023 Post an enquiry for this product
