Top Quality 5%, 50%, 98% Dihydromyricetin Powder / Dmy / Dihydromyricetincas 27200-12-0

Dihydromyricetin More Info

Dihydromyricetin is a dihydroflavonol compound, a specific flavonoid found abundantly in the Japanese raisin tree, with the CAS Registry Number 27200-12-0. Its molecular structure is characterized by a flavone backbone with a saturated bond in the C-ring and multiple hydroxyl groups, which contribute to its potent antioxidant and biological activities. This specific structural configuration, closely related to myricetin but with the saturated bond, enhances its stability and influences its interaction with biological targets. It typically appears as a white to off-white crystalline powder.

The biological activities of DHM are multifaceted and have been the subject of extensive research. Its most prominent and well-studied mechanism involves its action as a potent negative allosteric modulator of GABA-A receptors, particularly those containing extrasynaptic δ-subunits. This modulation reduces the intoxicating and sedative effects of ethanl, positioning it as a potential agent for mitigating alcohol intoxication and dependence. Additionally, it exhibits strong antioxidant, anti-inflammatory, hepatoprotective, and lipid-lowering effects through the modulation of various cellular signaling pathways.

The primary applications of DHM are in the fields of dietary supplements and biomedical research. It is widely marketed as a supplement for liver health, hangover relief, and to support metabolism and weight management. In scientific research, it is a valuable tool for studying GABAergic neurotransmission, alcohol-related behaviors, and metabolic syndrome. Its potential therapeutic roles are being explored for conditions including alcoholic liver disease, non-alcoholic fatty liver disease, anxiety, and as an adjunct in alcohol use disorder therapy.

From a pharmacokinetic and formulation perspective, DHM has moderate oral bioavailability. Its absorption can be influenced by factors such as food and formulation technology. To enhance its stability and absorption, advanced delivery systems like phospholipid complexes, nanoparticles, or cyclodextrin inclusion complexes are often employed in supplement products. It is generally administered orally in capsule or tablet form, with dosing based on extrapolation from animal studies and traditional use.