Most Professional Manufacturer Supply High Quality Irinotecan hydrochloride CAS 100286-90-6 in Bulk
100286-90-6
Pharmaceutical Grade
99%
Durban
Custom
As per customer requirement
Yes
2024-05-26
Sodium Lauryl Ether Sulfate,Caustic Soda,Soda Ash,Citric Acid,Calcium Hypochlorite,Oxalic Acid
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceYellow Crystalline PowderChEBI: A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancr as after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.lrinotecan hydrochlor
Irinotecan hydrochloride (anhydrous) is a hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antineoplastic agent, an apoptosis inducer and a prodrug. It contains an irinotecan(1+).|Irinotecan and topotecan are semisynthetic derivatives of the plant alkaloid camptothecin and are used as antineoplastic agents in the therapy of colorectal, ovarian and non-small cell lung cancer. Both irinotecan and topotecan are associated with an appreciable rate of serum enzyme elevations during therapy, and irinotecan has been implicated in causing steatohepatitis when given as cyclic anticancer therapy.|A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.Basic Info-
Product Name:
Irinotecan hydrochloride
Other Name:[1,4′-Bipiperidine]-1′-carboxylic acid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,hydrochloride (1:1);[1,4′-Bipiperidine]-1′-carboxylic acid,4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,monohydrochloride,(S)-;[1,4′-Bipiperidine]-1′-carboxylic acid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,monohydrochloride;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline,[1,4′-bipiperidine]-1′-carboxylic acid deriv.;CPT 11;Camptothecin 11;7-Ethyl-10-[[4-(1-piperidyl)-1-piperidyl]carbonyloxy]camptothecin hydrochloride;Camptothecin 11 hydrochloride;Irinotecan hydrochloride;U 101440E;Topotecin;Campto;Camptosar;Topotesin;(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate hydrochloride;111348-33-5
CAS No.:100286-90-6
Molecular Formula:C33H38N4O6.ClH
InChIKeys:InChIKey=GURKHSYORGJETM-WAQYZQTGSA-N
Molecular Weight:623.14
Exact Mass:622.255798
EC Number:1308068-626-2
UNII:06X131E4OE
NSC Number:759878|616348
DSSTox ID:DTXSID6045953
HScode:29399990
Categories:
Characteristics-
PSA:
113
XLogP3:4.76890
Appearance:Yellow crystalline powder
Melting Point:250-256°C (dec.)
Boiling Point:257 °C
Flash Point:482ºC
Refractive Index:67.7 ° (C=1, H2O)
Water Solubility:soluble in DMSO at 100mg/ml. soluble in water at 25mg/ml with warming;soluble in DMF at approximately 20mg/ml. Sparingly soluble in aqueous buffers.
Storage Conditions:Refrigerator
Vapor Pressure:1.31E-32mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Distributor
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Main Products:
Sodium Lauryl Ether Sulfate,Caustic Soda,Soda Ash,Citric Acid,Calcium Hypochlorite,Oxalic Acid
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Location:
13 PROTEA PARK MILKWOOD STREET RANGEVIEW GAUTENG 1739
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
60 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2012
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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