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119413-54-6 Topotecan hydrochloride buy - large image1
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119413-54-6 Topotecan hydrochloride

TDS

Unit Price: Get Latest Price
CAS No.:

119413-54-6

Grade:

Pharmaceutical Grade

Content:

0.98%

Port:

shanghai

Brand:

Ranhang

Packaging:

According to customers demand

Price valid (until):

2024-05-28

Company Type:
Trader
Location:
China
Qualification:
Main Products:

chemical

  • Product Description

  • Seller Information

  • Description

    Topotecan hydrochloride inhibits the activity of topoisomerase I, an enzyme required for DNA replication. After intravenous injection, this product is hydrolyzed in the blood and excreted in the urine. This product has a rapid serum clearance rate of 62L per hour, is widely distributed in the body, and has a half-life of approximately 2 to 3 hours. Preclinical tests show that this product has anti-tumor activity against various tumor types. In phase I clinical trials, this product also had significant anti-tumor effects in patients with ovarian cancer who were resistant to cisplatin.

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    Certificates
    • 119413-54-6 Topotecan hydrochloride Certificates 1

    Basic Info
    Product Name:

    Topotecan hydrochloride

    Other Name:

    1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,hydrochloride (1:1),(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,monohydrochloride,(S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,monohydrochloride,(4S)-;SKF 104864A;NSC 609669;Topotecan hydrochloride;Hycamtin;SKFS 104864A;Nogitecan hydrochloride;Topotecan chlorohydrate;(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride;Xinze

    CAS No.:

    119413-54-6

    Molecular Formula:

    C23H23N3O5.ClH

    InChIKeys:

    InChIKey=DGHHQBMTXTWTJV-BQAIUKQQSA-N

    Molecular Weight:

    457.91

    Exact Mass:

    421.163757

    EC Number:

    1308068-626-2

    UNII:

    956S425ZCY

    NSC Number:

    759263|609699

    DSSTox ID:

    DTXSID1045952

    NCI Thesaurus Code:

    C2828

    ATC Code:

    L01CE01

    HScode:

    29420000

    Characteristics
    PSA:

    103

    XLogP3:

    2.64880

    Appearance:

    White Crystalline Solid

    Density:

    1.5±0.1 g/cm3

    Melting Point:

    215 °C (decomp)

    Boiling Point:

    782.9ºC at 760mmHg

    Flash Point:

    427.3±32.9 °C

    Refractive Index:

    1.734

    Storage Conditions:

    Refrigerator

    Vapor Pressure:

    8.13E-26mmHg at 25°C

    Collision Cross Section:

    211.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Hazard Identification

    Classification of the substance or mixture

    Germ cell mutagenicity, Category 1B

    Carcinogenicity, Category 2

    Reproductive toxicity, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H340 May cause genetic defects

    H351 Suspected of causing cancer

    H361 Suspected of damaging fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    chemical

    Location:

    Room 237, Office Building, Shangma Yirui Industrial Park, 500 meters east of the intersection of Hedong Road and Longfei Road, Shangma Street, Chengyang District, Qingdao City, Shandong Province

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    2

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    5-10

    Year of Establishment:

    2023

  • Country Product Purchase Quantity Date Posted
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