Nedaplatin
95734-82-0
Industrial Grade
98%
25kg/Cardboard Drum
Yes
2024-05-29
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceNedaplatin is a derivative of cisplatin and DNA damage agent.Target: OthersNedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of NDP at microgram/milliliter concentrations [1]. NDP was developed as a se
Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.Basic Info-
Product Name:
Nedaplatin
Other Name:Platinum,diammine[2-(hydroxy-κO)acetato(2-)-κO]-,(SP-4-3)-;Platinum,diammine[hydroxyacetato(2-)-O1,O2]-,(SP-4-3)-;Platinum,diammine[(hydroxy-κO)acetato(2-)-κO]-,(SP-4-3)-;Acetic acid,hydroxy-,platinum complex;(SP-4-3)-Diammine[2-(hydroxy-κO)acetato(2-)-κO]platinum;254S;S 254;Nedaplatin;NSC 375101;Aqupla
CAS No.:95734-82-0
Molecular Formula:C2H8N2O3Pt
InChIKeys:InChIKey=GYAVMUDJCHAASE-UHFFFAOYSA-M
Molecular Weight:303.17
Exact Mass:303.018280
NSC Number:375101
DSSTox ID:DTXSID8046878
NCI Thesaurus Code:C61099
Categories:
Characteristics-
PSA:
59.5
Flash Point:128.7ºC
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Location:
Room 507, Dongnan Technology R&D Center, No.438 Jincheng Road, Beigan Street, Xiaoshan District,Hangzhou City,Zhengjiang Province,China
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
20 days
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
51-100
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Year of Establishment:
2013
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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