Factory Price Deoxycholic acid CAS NO (83-44-3) In Wholesale Price

Comprehensive Overview of Deoxycholic Acid (83-44-3):

Introduction: Deoxycholic acid is a bile acid compound belonging to the class of steroidal compounds. It plays a crucial role in the digestion and absorption of dietary fats and is also utilized in various medical and cosmetic applications due to its ability to disrupt lipid membranes and solubilize fat deposits.

Chemical Structure and Properties: Deoxycholic acid has the chemical formula C24H40O4 and is a secondary bile acid derived from the metabolism of cholesterol in the liver. Structurally, it is characterized by a cyclopentanophenanthrene nucleus with a carboxylic acid group and several hydroxyl groups. Deoxycholic acid is a white crystalline powder with a molecular weight of approximately 392.57 g/mol.

Physiological Function: In the body, deoxycholic acid is synthesized from cholic acid in the liver and released into the small intestine, where it aids in the digestion and absorption of dietary fats and fat-soluble vitamins. It facilitates the emulsification of lipids, enhances the solubilization of fat globules, and promotes the formation of mixed micelles for efficient absorption in the intestinal tract.

Medical Applications:

1. Gallstone Dissolution: Deoxycholic acid has been used in medical therapy for the dissolution of cholesterol gallstones, particularly in patients who are not candidates for surgery. By increasing the solubility of cholesterol in bile, deoxycholic acid helps dissolve gallstones over time when administered orally or intravenously under medical supervision.
2. Treatment of Xanthelasma: Xanthelasma are yellowish cholesterol-rich deposits that form under the skin, typically around the eyelids. Deoxycholic acid injections have been investigated as a treatment option for xanthelasma, as it can disrupt the lipid-rich deposits and promote their absorption and clearance by the body.
3. Submental Fat Reduction: Deoxycholic acid is approved by regulatory agencies in various countries, including the FDA in the United States, for the treatment of submental fat, commonly known as "double chin." Injected directly into subcutaneous fat tissue, deoxycholic acid disrupts fat cell membranes, leading to adipocyte lysis and subsequent reduction in localized fat deposits.

Cosmetic and Aesthetic Applications:

1. Non-Surgical Fat Reduction: Deoxycholic acid injections are commonly used in cosmetic dermatology for non-surgical fat reduction and body contouring procedures. It is particularly effective for reducing submental fat, as well as localized fat deposits in areas such as the abdomen, flanks, thighs, and buttocks.
2. Kybella®: Kybella® is a branded formulation of synthetic deoxycholic acid approved for cosmetic use in the treatment of submental fat. It is administered via a series of injections into the submental area to achieve a more contoured and defined jawline without the need for surgery or liposuction.
3. Safety and Side Effects: While deoxycholic acid injections are generally considered safe when administered by qualified healthcare professionals, common side effects may include temporary swelling, bruising, redness, and discomfort at the injection site. Rare but serious complications such as nerve injury, skin necrosis, and dysphagia have been reported.

Research and Future Directions: Research into the therapeutic potential of deoxycholic acid continues to explore its applications in lipid metabolism, cholesterol homeostasis, and bile acid signaling pathways. Additionally, investigations into novel formulations and delivery methods for deoxycholic acid are ongoing to optimize its efficacy and safety in medical and cosmetic interventions.

Conclusion: Deoxycholic acid is a bile acid compound with important physiological functions in lipid digestion and absorption. Its applications extend beyond digestion to include medical therapy for gallstone dissolution and xanthelasma treatment, as well as cosmetic treatments for submental fat reduction and body contouring. Continued research and clinical advancements are expected to further elucidate the therapeutic potential and safety profile of deoxycholic acid in various medical and aesthetic applications.