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Irinotecan hydrochloride CAS NO (100286-90-6) Available at good price

Name: Irinotecan hydrochloride CAS NO (100286-90-6) Available at good price
Brand: Custom
SKU: pr2404301065
Price: 100 USD
Availability: InStock

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CAS No.:

100286-90-6

Grade:

Industrial Grade

Content:

99%

Port:

Durban

Brand:

Custom

Packaging:

As per customer requirement

Sample Available:

Yes

Price valid (until):

2024-05-30

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Conex Chemicals PTY Ltd

Company Type:

Distributor

Location:

South Africa

Payment Terms:

TT against copy of documents,TT against B/L draft before shipment

Average Lead Time:

60 days

Qualification:

Main Products:

Sodium Lauryl Ether Sulfate,Caustic Soda,Soda Ash,Citric Acid,Calcium Hypochlorite,Oxalic Acid

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Product Details
Seller Information

Description

Product Detail

1. - 1. 1. Title: Irinotecan Hydrochloride (100286-90-6): Synthesis, Mechanism of Action, and Clinical Applications
        
        Introduction to Irinotecan Hydrochloride (100286-90-6)
        
        Irinotecan hydrochloride is a chemotherapeutic agent used in the treatment of various cancers, including colorectal cancer.
        
        This review aims to explore the synthesis, mechanism of action, and clinical applications of irinotecan hydrochloride.
        
        Chemical Structure and Synthesis
        
        Irinotecan hydrochloride is a semi-synthetic derivative of camptothecin, a natural alkaloid isolated from the Chinese tree Camptotheca acuminata.
        
        The synthesis of irinotecan hydrochloride involves several steps, including chemical modifications of camptothecin to enhance its pharmacological properties and water solubility.
        
        Mechanism of Action
        
        Irinotecan hydrochloride exerts its anticancer effects by inhibiting topoisomerase I, an enzyme involved in DNA replication and repair.
        
        It stabilizes the topoisomerase I-DNA complex, leading to DNA strand breaks and ultimately cell death in proliferating cancer cells.
        
        Pharmacokinetics
        
        Irinotecan hydrochloride is administered intravenously and undergoes rapid conversion to its active metabolite, SN-38, in the liver.
        
        SN-38 is responsible for the cytotoxic effects of irinotecan and is further metabolized by glucuronidation to inactive forms.
        
        Clinical Applications
        
        Irinotecan hydrochloride is used as a component of combination chemotherapy regimens for the treatment of colorectal cancer, both in the adjuvant and metastatic settings.
        
        It is also employed in the management of other solid tumors, including lung, pancreatic, and gastric cancers, either as monotherapy or in combination with other chemotherapeutic agents.
        
        Adverse Effects
        
        Common adverse effects of irinotecan hydrochloride include gastrointestinal toxicity, myelosuppression, fatigue, and alopecia.
        
        Diarrhea is a dose-limiting toxicity associated with irinotecan therapy and can be managed with supportive care and dose adjustments.
        
        Resistance Mechanisms
        
        Resistance to irinotecan hydrochloride can occur through various mechanisms, including alterations in drug metabolism, drug efflux, and DNA repair pathways.
        
        Understanding these resistance mechanisms is essential for developing strategies to overcome treatment resistance and improve clinical outcomes.
        
        Future Perspectives
        
        Ongoing research efforts focus on elucidating the molecular mechanisms underlying the antitumor effects of irinotecan hydrochloride and identifying predictive biomarkers of treatment response.
        
        Novel drug delivery systems and combination therapies are being explored to enhance the efficacy and reduce the toxicity of irinotecan-based chemotherapy regimens.
        
        Clinical Trials and New Indications
        
        Clinical trials are evaluating the efficacy of irinotecan hydrochloride in combination with targeted therapies, immunotherapies, and radiation therapy for various cancer types.
        
        New indications for irinotecan hydrochloride are being investigated, including its use in pediatric cancers and rare malignancies.
        
        Conclusion: Role of Irinotecan Hydrochloride in Cancer Therapy
        
        Irinotecan hydrochloride plays a crucial role in the treatment of various cancers, particularly colorectal cancer, and continues to be an important component of standard chemotherapy regimens.
        
        Continued research efforts aim to optimize its use, improve treatment outcomes, and expand its therapeutic applications in oncology.

Specifications

Items	Specifications
CAS Number	100286-90-6
Chemical Formula	C33H39ClN4O6
Molecular Weight	Approximately 623.14 g/mol
Appearance	White to off-white crystalline powder
Purity	≥ 98%
Melting Point	250-255°C (decomposes)
Boiling Point	Not available
Density	Not available
Solubility	Soluble in water, slightly soluble in methanol
Storage	Store in a cool, dry place away from heat and moisture
Stability	Stable under normal conditions
Odor	Odorless
Applications	Antineoplastic agent used in the treatment of colorectal cancer and other malignancies

CAS Number	106-33-2
Chemical Formula	C14H28O2
Molecular Weight	Approximately 228.37 g/mol
Appearance	Colorless to pale yellow liquid
Purity	≥ 98%
Melting Point	-15 to -13°C
Boiling Point	270-273°C
Density	0.874 g/cm³
Refractive Index	1.421-1.423 at 20°C
Flash Point	111°C (closed cup)
Solubility	Insoluble in water, soluble in organic solvents
Storage	Store in a cool, dry place away from heat and moisture
Stability	Stable under normal conditions
Odor	Fruity, waxy
Applications	Flavoring agent, fragrance ingredient, solvent, intermediate in organic synthesis

Product Pictures

ECHEMI Editorial Reference

Yellow Crystalline PowderChEBI: A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancr as after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.lrinotecan hydrochlor
Irinotecan hydrochloride (anhydrous) is a hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antineoplastic agent, an apoptosis inducer and a prodrug. It contains an irinotecan(1+).|Irinotecan and topotecan are semisynthetic derivatives of the plant alkaloid camptothecin and are used as antineoplastic agents in the therapy of colorectal, ovarian and non-small cell lung cancer. Both irinotecan and topotecan are associated with an appreciable rate of serum enzyme elevations during therapy, and irinotecan has been implicated in causing steatohepatitis when given as cyclic anticancer therapy.|A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.

Basic Info

Product Name:

Irinotecan hydrochloride

Other Name:

[1,4′-Bipiperidine]-1′-carboxylic acid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,hydrochloride (1:1);[1,4′-Bipiperidine]-1′-carboxylic acid,4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,monohydrochloride,(S)-;[1,4′-Bipiperidine]-1′-carboxylic acid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,monohydrochloride;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline,[1,4′-bipiperidine]-1′-carboxylic acid deriv.;CPT 11;Camptothecin 11;7-Ethyl-10-[[4-(1-piperidyl)-1-piperidyl]carbonyloxy]camptothecin hydrochloride;Camptothecin 11 hydrochloride;Irinotecan hydrochloride;U 101440E;Topotecin;Campto;Camptosar;Topotesin;(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate hydrochloride;111348-33-5

CAS No.:

100286-90-6

Molecular Formula:

C33H38N4O6.ClH

InChIKeys:

InChIKey=GURKHSYORGJETM-WAQYZQTGSA-N

Molecular Weight:

623.14

Exact Mass:

622.255798

EC Number:

1308068-626-2

UNII:

06X131E4OE

NSC Number:

759878|616348

DSSTox ID:

DTXSID6045953

HScode:

29399990

Categories:

Plant Extracts

Characteristics

PSA:

113

XLogP3:

4.76890

Appearance:

Yellow crystalline powder

Melting Point:

250-256°C (dec.)

Boiling Point:

257 °C

Flash Point:

482ºC

Refractive Index:

67.7 ° (C=1, H2O)

Water Solubility:

soluble in DMSO at 100mg/ml. soluble in water at 25mg/ml with warming;soluble in DMF at approximately 20mg/ml. Sparingly soluble in aqueous buffers.

Storage Conditions:

Refrigerator

Vapor Pressure:

1.31E-32mmHg at 25°C

See More Irinotecan hydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Irinotecan hydrochloride Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Sodium Lauryl Ether Sulfate,Caustic Soda,Soda Ash,Citric Acid,Calcium Hypochlorite,Oxalic Acid

Location:
13 PROTEA PARK MILKWOOD STREET RANGEVIEW GAUTENG 1739

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment

Average lead Time:
60 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2012
Country Product Purchase Quantity Date Posted

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Irinotecan hydrochloride CAS NO (100286-90-6) Available at good price

Product Details

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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