SAFETY DATA SHEETS
According to the UN GHS revision 9
Version: 1.0
Creation Date: July 15, 2019
Revision Date: July 15, 2019
SECTION 1: Identification
1.1GHS Product identifier
| Product name | Benzothiazole-2-thiol |
1.2Other means of identification
| Product number | - |
| Other names | mercaptobenzothiazole; AG 63; 2(3H)-Benzothiazolethione |
1.3Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research use. |
| Uses advised against | no data available |
SECTION 2: Hazard identification
2.1Classification of the substance or mixture
Skin sensitization, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2GHS label elements, including precautionary statements
| Pictogram(s) |   |
| Signal word | Warning |
| Hazard statement(s) | H317 May cause an allergic skin reaction H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) |
| Prevention | P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P391 Collect spillage. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3Other hazards which do not result in classification
SECTION 3: Composition/information on ingredients
3.1Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
| Benzothiazole-2-thiol | Benzothiazole-2-thiol | 149-30-4 | 205-736-8 | 100% |
SECTION 4: First-aid measures
4.1Description of necessary first-aid measures
If inhaled
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
4.2Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound may include allergic contact dermatitis. Skin contact may also lead to sensitization. Eye contact can cause irritation. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is very irritating to the eyes. When heated to decomposition or upon contact with acid or acid fumes, it emits highly toxic fumes of carbon monoxide, carbon dioxide, sulfur oxides and nitrogen oxides. (NTP, 1992)
4.3Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds
SECTION 5: Fire-fighting measures
5.1Suitable extinguishing media
Suitable extinguishing media: Use water spray, alchohol-resistant foam, dry chemical or carbon dioxide.
5.2Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
5.3Special protective actions for fire-fighters
Use water spray, dry powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Personal protection: face shield and particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3Methods and materials for containment and cleaning up
Personal precautions, protective equipment and emergency procedure: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust.
SECTION 7: Handling and storage
7.1Precautions for safe handling
NO open flames. PREVENT DISPERSION OF DUST. Closed system, dust explosion-proof electrical equipment and lighting. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2Conditions for safe storage, including any incompatibilities
Separated from acids.Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.
SECTION 8: Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
MAK: (inhalable fraction): 4 mg/m3; carcinogen category: 3B; sensitization of skin (SH); pregnancy risk group: C
Biological limit values
8.2Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Solid. Crystalline. |
| Colour | Yellow. |
| Odour | Disagreeable odor |
| Melting point/freezing point | 180 - 182 °C. |
| Boiling point or initial boiling point and boiling range | 64°C/4mmHg |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 200 °C. |
| Auto-ignition temperature | 628°C |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 66° F (NTP, 1992) |
| Partition coefficient n-octanol/water | log Pow = 2.42. |
| Vapour pressure | < 0 hPa. Temperature:25 °C. |
| Density and/or relative density | 1.42 g/cm³. Temperature:20 °C. |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1Reactivity
Decomposes on burning. This produces toxic and irritating fumes (sulfur oxides, nitrogen oxides). Reacts with acids and acid fumes. This produces toxic and irritating fumes (sulfur oxides, nitrogen oxides).
10.2Chemical stability
10.3Possibility of hazardous reactions
2-MERCAPTOBENZOTHIAZOLE is incompatible with strong oxidizing agents. Also incompatible with acids and acid fumes (NTP, 1992).
10.4Conditions to avoid
10.5Incompatible materials
on contact with acid or acid fumes it emits toxic /oxides of sulfur and oxides of nitrogen/.
10.6Hazardous decomposition products
When heated to decomp ... it emits toxic /oxides of sulfur and oxides of nitrogen/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - 3 800 mg/kg bw. Remarks:Clinical signs: reduced appetite and activity, increased weakness, collapse and death.
- Inhalation: LC50 - rat (male/female) - > 1 270 mg/L air.
- Dermal: LD50 - rabbit (male/female) - > 7 940 mg/kg bw.
Skin corrosion/irritation
Serious eye damage/irritation
Respiratory or skin sensitization
Germ cell mutagenicity
Carcinogenicity
Cancer Classification: Group C Possible Human Carcinogen
Reproductive toxicity
STOT-single exposure
The substance may be irritating to the eyes.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. See Notes. This substance is probably carcinogenic to humans.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached.
SECTION 12: Ecological information
12.1Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 0.73 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 0.71 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 0.5 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge - 3 301 mg/L - 3 h. Remarks:Respiration rate.
12.2Persistence and degradability
AEROBIC: Several biodegradation studies with 2-mercaptobenzothiazole using an activated sludge seed inoculum indicate little or no biodegration(1-4). 2-Mercaptobenzothiazole, present at 100 mg/L, reached only 2.5% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test indicating the compound is not readily biodegradable(1). It has been suggested that at the concentrations used in these studies, 56-100 ppm, 2-mercaptobenzothiazole is toxic to the microorganisms in the sludge(5). A more detailed study indicated that inhibitory effects occur between 20 and 50 ppm of 2-mercaptobenzothiazole(5). When the sludge is well acclimated and the concentrations low enough, 2-mercaptobenzothiazole may completely biodegrade forming 2-benzothiazolesulfonate or dibenzothiazole-2,2-disulfide, depending on conditions(5). In a screening test comparable to OECD Method 301B (CO2 evolution), 2-mercaptobenzothiazole, present at 17-18 mg/L, reached only 1-5% degradation after 35 days of incubation which classified the compound as not inherently biodegradable(6). Another CO2 evolution study determined <1% degradation after 28 days using adapted activated sludge and an initial 2-mercaptobenzothiazole concentration of 23.8 mg/L(6). Partial degradation of 2-mercaptobenzothiazole was found in laboratory-scale fed-batch systems using activated sludge inoculum taken from rubber chemicals wastewater treatment plants(6).
12.3Bioaccumulative potential
A BCF of <8 was measured in fish for 2-mercaptobenzothiazole(SRC), using carp (Cyprinus carpio) which were exposed over a 6-week period(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4Mobility in soil
The Koc of 2-mercaptobenzothiazole was measured as 677, 326 and 1360 in California sandy loam, California clay loam and California sandy soil respectively(1). The Koc of 2-mercaptobenzothiazole was measured as 2130, 3560 and 2590 in three different sediments(1). The Koc of 2-mercaptobenzothiazole was measured as 915, 863, 1429 and 1829 in Drummer silty clay loam, Spinks sandy loam, Ray silt loam and Lintonia sandy loam soil respectively(1). According to a classification scheme(2), these estimated Koc values suggest that 2-mercaptobenzothiazole is expected to have moderate to slight mobility in soil. The pKa of 2-mercaptobenzothiazole is 7.03(1), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(3).
12.5Other adverse effects
SECTION 13: Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1UN Number
| ADR/RID: UN3077 (For reference only, please check.) | IMDG: UN3077 (For reference only, please check.) | IATA: UN3077 (For reference only, please check.) |
14.2UN Proper Shipping Name
| ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.) | IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.) | IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.) |
14.3Transport hazard class(es)
| ADR/RID: 9 (For reference only, please check.) | IMDG: 9 (For reference only, please check.) | IATA: 9 (For reference only, please check.) |
14.4Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6Special precautions for user
14.7Transport in bulk according to IMO instruments
SECTION 15: Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
| Benzothiazole-2-thiol | Benzothiazole-2-thiol | 149-30-4 | 205-736-8 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. |
| EC Inventory | Listed. |
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. |
| China Catalog of Hazardous chemicals 2015 | Not Listed. |
| New Zealand Inventory of Chemicals (NZIoC) | Listed. |
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. |
| Vietnam National Chemical Inventory | Listed. |
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
| Korea Existing Chemicals List (KECL) | Listed. |
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
ECHEMI Editorial Reference
beige or light yellow powder with a faint odourChEBI: 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.Pale yellow to tan crystalline powder with a disagreeable odor.
India
Pakistan
China
