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Home > Pharmaceutical Intermediates > Cardiovascular Agents > Manidipine dihydrochloride for Sale > Antihypertensive Manidipine Hydrochloride API Manidipine HCl Powder Purity Manidipine Hydrochloride
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Antihypertensive Manidipine Hydrochloride API Manidipine HCl Powder Purity Manidipine Hydrochloride

Unit Price:

$10-12/KG FOB

Get Latest Price
CAS No.:

89226-75-5

Port:

Shanghai

Packaging:

25kg/cardboard drum

Price valid (until):

2080-01-01

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Tris,Octorylene

  • Product Description

  • Seller Information

  • Description

    Basic Info.

    Model NO.
    D-sung Manidipine Hydrochloride
    Product Name
    Manidipine Hydrochloride
    Name
    Manidipine HCl
    Appearance
    White Powder
    Color
    White
    Grade
    Pharmaceutical Grade
    Assay
    HPLC 99%
    Application
    Pharmaceutical;Antihyperation;Antihypertensive
    Specific
    COA
    Test Method
    HPLC
    Shelf Life
    2 Years
    CAS No.
    89226-75-5
    Mf
    C35h40cl2n4o6
    MW
    683.627
    Melting Point
    228-235°c
    Boiling Point
    722 °c at 760 Mmhg
    Transport Package
    Negotiable
    Specification
    99%
    Origin
    Product Description

    Antihypertensive Manidipine Hydrochloride API Manidipine HCL Powder Purity Manidipine Hydrochloride
    Product Description


    Product name Manidipine Hydrochloride
    Cas number 89226-75-5
    Appearance White powder
    MF C35H40Cl2N4O6
    MW 683.627

    Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.

    Application&Function

    Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature,presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound.

    Shop Antihypertensive Manidipine Hydrochloride API Manidipine HCl Powder Purity Manidipine Hydrochloride-Detailed Image 1



    Basic Info
    Product Name:

    Manidipine dihydrochloride

    Other Name:

    3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester,hydrochloride (1:2);3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester,dihydrochloride;CV 4093;Franidipine hydrochloride;(±)-Manidipine dihydrochloride;Calslot;Manidipine dihydrochloride;126229-12-7

    CAS No.:

    89226-75-5

    Molecular Formula:

    C35H38N4O6.2ClH

    InChIKeys:

    InChIKey=JINNGBXKBDUGQT-UHFFFAOYSA-N

    Molecular Weight:

    683.62

    Exact Mass:

    682.232

    EC Number:

    1308068-626-2

    DSSTox ID:

    DTXSID9020796

    HScode:

    2933990090

    Categories:

    Cardiovascular Agents

    Characteristics
    PSA:

    117

    XLogP3:

    6.48280

    Melting Point:

    157-163°; mp 174-180°; mp 167-170°

    Boiling Point:

    722ºC at 760 mmHg

    Water Solubility:

    Soluble in DMSO. Slightly soluble in water and ethanol /n

    Toxicity:

    LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Reproductive toxicity, Category 2

    Specific target organ toxicity – repeated exposure, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H361 Suspected of damaging fertility or the unborn child

    H373 May cause damage to organs through prolonged or repeated exposure

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P318 IF exposed or concerned, get medical advice.

    P319 Get medical help if you feel unwell.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Tris,Octorylene

    Location:

    Eloor 17 , Block B, Poly Times

    Payment Terms:

    100% TT in advance

    Average lead Time:

    60

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    11-50

    Year of Establishment:

    2016

    Certifications:

    Registeration for Foreign Trade,SGS

    Hubei Marvel-Bio Medicine Co., Ltd. is located in Wuhan City, Hubei Province, the water, land and air transportation hub. The company is committed to the development and sales of fine chemicals, Pharmaceutical raw materials and other products.
    The company is committed to developing into a powerful brand company. The company has independent import and export rights.
    Innovative and breakthrough products not only make Marvel-Bio Medicine become the industry leader in China, but also enjoy a high reputation in the world. Always adhere to the business philosophy of "customer satisfaction, enterprise development", the company builds a bridge with customers in the spirit of integrity and dedication, and serves customers better, faster and more accurately.
    The company has independent import and export rights and excellent sales team. With the hard work of all employees, our company has opened a broad market. The company's products sell well all over the country and are exported to Europe, America, Southeast Asia and Africa and other countries and regions. The company serves more than 2000 customers every year, and has won unanimous recognition and praise from our customers.

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